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Sodium zirconium cyclosilicate Side Effects

Medically reviewed by Last updated on Oct 5, 2020.

For the Consumer

Applies to sodium zirconium cyclosilicate: oral powder for suspension

Side effects requiring immediate medical attention

Along with its needed effects, sodium zirconium cyclosilicate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium zirconium cyclosilicate:

More common

  • Swelling

Less common

For Healthcare Professionals

Applies to sodium zirconium cyclosilicate: oral powder for reconstitution


The most commonly reported adverse reactions reported during clinical trials included edema and hypokalemia.[Ref]


Very common (10% or more): Edema (up to 16.1%)

During clinical trials, edema was reported in 4.4% of patients receiving 5 g/day, 5.9% of patients receiving 10 g/day and 16.1% of patients receiving 15 g/day for up to 28 days (placebo 2.4%). In longer-term trials, 8% to 11% of patients receiving doses less than 15 g/day reported edema, generalized edema and peripheral edema.


Common (1% to 10%): Hypokalemia

Frequency not reported: Increase in sodium bicarbonate concentrations

In clinical trials, 4.1% of patients developed hypokalemia which resolved with dose reduction or discontinuation.

Small, dose-dependent increases in sodium bicarbonate occurred with once daily dosing (1.1 mmol/L at 5 g/day; 2.3 mmol/L at 10 g/day; 2.6 mmol/L at 15 g/day; 0.6 mmol/L in placebo). The clinical significance of this is unknown.


1. "Product Information. Lokelma (sodium zirconium cyclosilicate)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.