Sodium zirconium cyclosilicate Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 5, 2020.
For the Consumer
Applies to sodium zirconium cyclosilicate: oral powder for suspension
Side effects requiring immediate medical attention
Along with its needed effects, sodium zirconium cyclosilicate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sodium zirconium cyclosilicate:
- Decreased urine
- dry mouth
- increased thirst
- irregular heartbeat
- loss of appetite
- mood changes
- muscle pain or cramps
- numbness or tingling in the hands, feet, or lips
- unusual tiredness or weakness
For Healthcare Professionals
Applies to sodium zirconium cyclosilicate: oral powder for reconstitution
Very common (10% or more): Edema (up to 16.1%)
During clinical trials, edema was reported in 4.4% of patients receiving 5 g/day, 5.9% of patients receiving 10 g/day and 16.1% of patients receiving 15 g/day for up to 28 days (placebo 2.4%). In longer-term trials, 8% to 11% of patients receiving doses less than 15 g/day reported edema, generalized edema and peripheral edema.
Common (1% to 10%): Hypokalemia
Frequency not reported: Increase in sodium bicarbonate concentrations
In clinical trials, 4.1% of patients developed hypokalemia which resolved with dose reduction or discontinuation.
Small, dose-dependent increases in sodium bicarbonate occurred with once daily dosing (1.1 mmol/L at 5 g/day; 2.3 mmol/L at 10 g/day; 2.6 mmol/L at 15 g/day; 0.6 mmol/L in placebo). The clinical significance of this is unknown.
1. "Product Information. Lokelma (sodium zirconium cyclosilicate)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Frequently asked questions
More about sodium zirconium cyclosilicate
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- Drug class: cation exchange resins
- Other brands
Related treatment guides
Some side effects may not be reported. You may report them to the FDA.