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Sodium Zirconium Cyclosilicate Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 21, 2025.

Applies to sodium zirconium cyclosilicate: oral powder for suspension.

Serious side effects

Along with its needed effects, sodium zirconium cyclosilicate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium zirconium cyclosilicate:

More common side effects

  • swelling

Less common side effects

  • decreased urine
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea
  • numbness or tingling in the hands, feet, or lips
  • seizures
  • unusual tiredness or weakness
  • vomiting

Managing side effects (general information)

For healthcare professionals

Applies to sodium zirconium cyclosilicate: oral powder for reconstitution.

General adverse events

The most commonly reported adverse reactions reported during clinical trials included edema and hypokalemia.[Ref]

Cardiovascular

During clinical trials, edema was reported in 4.4% of patients receiving 5 g/day, 5.9% of patients receiving 10 g/day and 16.1% of patients receiving 15 g/day for up to 28 days (placebo 2.4%). In longer-term trials, 8% to 11% of patients receiving doses less than 15 g/day reported edema, generalized edema and peripheral edema.

Metabolic

In clinical trials, 4.1% of patients developed hypokalemia which resolved with dose reduction or discontinuation.

Small, dose-dependent increases in sodium bicarbonate occurred with once daily dosing (1.1 mmol/L at 5 g/day; 2.3 mmol/L at 10 g/day; 2.6 mmol/L at 15 g/day; 0.6 mmol/L in placebo). The clinical significance of this is unknown.

References

1. (2018) "Product Information. Lokelma (sodium zirconium cyclosilicate)." Astra-Zeneca Pharmaceuticals

Frequently asked questions

Further information

Sodium zirconium cyclosilicate side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer