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Sodium Zirconium Cyclosilicate Dosage

Medically reviewed by Drugs.com. Last updated on Oct 21, 2020.

Applies to the following strengths: 5 g; 10 g

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hyperkalemia

Initial dose: 10 g orally 3 times a day for up to 48 hours
-Dose should be adjusted based on serum potassium level and desired target range; dose may be up-titrated at weekly or greater intervals in 5 g increments
Maintenance dose: 10 g orally once a day; range: 5 g once a day every other day to 15 g once a day

Comments:
-This drug should not be used for the emergency treatment of life-threatening hyperkalemia because of its delayed onset of action.
-Normal potassium levels are generally achieved within 24 to 48 hours; once normal potassium levels are achieved, the minimal effective maintenance dose should be established.
-Dose should be decreased or discontinued if serum potassium is below the desired target range.

Use: For the treatment of hyperkalemia.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally as a suspension in water
-Other oral medications should be administered at least 2 hours before or 2 hours after this drug (see general comments)

Reconstitution/preparation techniques:
-Empty entire contents of packet(s) into approximately 3 tablespoons of water; stir well and drink immediately; if powder remains, add water, stir and drink immediately; repeat until no powder remains
-Volume of water may be increased as long as entire contents is consumed and no powder remains

General:
-This drug may transiently increase gastric pH; therefore, the absorption of drugs that exhibit pH-dependent solubility may be altered when taken at the same time as this drug. In general, other oral medications should be administered at least 2 hours before or 2 hours after taking this drug unless the concomitantly administered drug does not exhibit pH-dependent solubility.
-This drug has been studied in patients with diseases such as chronic kidney disease, heart failure, and diabetes mellitus.

Monitoring:
-Monitor serum potassium levels as clinically indicated
-Monitor for signs of edema

Patient advice:
-Patients should be instructed on proper reconstitution and administration of this drug.
-Patients should be advised to adjust sodium, if appropriate.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.