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Seromycin Pulvules Side Effects

Generic Name: cycloserine

Note: This page contains side effects data for the generic drug cycloserine. It is possible that some of the dosage forms included below may not apply to the brand name Seromycin Pulvules.

For the Consumer

Applies to cycloserine: oral capsule

As well as its needed effects, cycloserine (the active ingredient contained in Seromycin Pulvules) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking cycloserine, check with your doctor immediately:

More common:
  • Anxiety
  • confusion
  • dizziness
  • drowsiness
  • increased irritability
  • increased restlessness
  • mental depression
  • muscle twitching or trembling
  • nervousness
  • nightmares
  • other mood or mental changes
  • speech problems
  • thoughts of suicide
Less common:
  • Convulsions (seizures)
  • numbness, tingling, burning pain, or weakness in the hands or feet
  • skin rash

Minor Side Effects

Some cycloserine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Headache

For Healthcare Professionals

Applies to cycloserine: oral capsule


Cycloserine (the active ingredient contained in Seromycin Pulvules) is most frequently associated with neurotoxicity and hypersensitivity.[Ref]

Nervous system

Nervous system side effects may be dose-related (> 500 mg/day) and have included convulsions, drowsiness, somnolence, headache, tremor, dysarthria, vertigo, confusion, disorientation, loss of memory, psychoses, suicidal tendencies, character changes, hyperirritability, aggression, paresis, hyperreflexia, paresthesia, major and localized seizures, and coma.[Ref]


Hematologic side effects have included vitamin B12 deficiency, folic acid deficiency, megaloblastic anemia, and sideroblastic anemia.[Ref]


Hepatic side effects have included elevated serum transaminases, particularly in patients with preexisting liver disease.[Ref]


Hypersensitivity reactions have included skin rash.[Ref]


Cardiovascular side effects have included sudden development of congestive heart failure in patients receiving high doses (1 to 1.5 g/day).[Ref]


1. "Product Information. Seromycin (cycloserine)." Dura Pharmaceuticals, San Diego, CA.

It is possible that some side effects of Seromycin Pulvules may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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