Skip to Content

Cycloserine Dosage

Applies to the following strength(s): 250 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Tuberculosis - Extrapulmonary

500 mg to 1 g orally per day, in 1 or 2 divided doses (10 to 15 mg/kg/day).

Duration: Treatment should continue until permanent bacteriological conversion and maximal clinical improvement have occurred, generally, 18 to 24 months.

Usual Adult Dose for Tuberculosis - Active

500 mg to 1 g orally per day, in 1 or 2 divided doses (10 to 15 mg/kg/day).

Duration: Treatment should continue until permanent bacteriological conversion and maximal clinical improvement have occurred, generally, 18 to 24 months.

Usual Pediatric Dose for Tuberculosis - Extrapulmonary

Children: 10 to 15 mg/kg/day in 2 divided doses

Maximum dose: 1 g/day

Usual Pediatric Dose for Tuberculosis - Active

Children: 10 to 15 mg/kg/day in 2 divided doses

Maximum dose: 1 g/day

Renal Dose Adjustments

Adults:
CrCl<50 mL/min: 250 mg/day or 500 mg 3 times a week

The use of cycloserine is not recommended in patients with CrCl<50 mL/minute unless they are on hemodialysis.

Liver Dose Adjustments

No adjustment recommended

Precautions

Cycloserine is contraindicated in patients with epilepsy, depression, severe anxiety, psychosis, or excessive alcohol use.

Cycloserine should be discontinued or the dosage reduced if allergic dermatitis or CNS toxicity (e.g., convulsions, psychosis, somnolence, depression, confusion, hyperreflexia, headache, tremor, vertigo, paresis, or dysarthria) occurs.

Blood concentrations > 30 mcg/mL are associated with toxicity. Patients taking more than 500 mg/day or with renal impairment should be closely monitored for CNS toxicity and blood concentrations monitoring should be measured weekly. Anticonvulsant agents may be helpful in controlling some symptoms. Pyridoxine may be useful in preventing CNS toxicity.

Regular hematologic, renal, hepatic, and blood level monitoring is recommended. The dose should be adjusted to maintain concentrations < 30 mcg/mL.

Due to rapid development of resistance, cycloserine should not be used alone for the treatment of tuberculosis. It should be given with other drugs to which the organism is susceptible.

Directly-observed treatment (DOT) is recommended for all antituberculosis therapy.

Dialysis

Adults:
Hemodialysis: 250 mg once a day or 500 mg 3 times a week, after dialysis sessions.

Other Comments

Concomitant pyridoxine may be useful in preventing some neurotoxic effects.

Peak serum concentrations of 20 to 35 mcg/mL are recommended when determining dosage.

Hide