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Requip Side Effects

Generic Name: ropinirole

Note: This page contains side effects data for the generic drug ropinirole. It is possible that some of the dosage forms included below may not apply to the brand name Requip.

In Summary

Common side effects of Requip include: syncope, dizziness, drowsiness, dyskinesia, fatigue, nausea, and viral infection. Other side effects include: asthenia, confusion, lower extremity edema, and diaphoresis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ropinirole: oral tablet, oral tablet extended release

As well as its needed effects, ropinirole (the active ingredient contained in Requip) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ropinirole, check with your doctor immediately:

More common:
  • Confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • drowsiness
  • falling
  • nausea
  • seeing, hearing, or feeling things that are not there (hallucinations)
  • sleepiness or unusual drowsiness
  • swelling of the legs
  • twisting, twitching, or other unusual body movements
  • unusual tiredness or weakness
  • worsening of parkinsonism
Less common:
  • Abdominal or stomach pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • blurred vision
  • burning, pain, or difficulty in urinating
  • chest pain
  • chills
  • cold sweats
  • cough
  • double vision or other eye or vision problems
  • fainting
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • high or low blood pressure
  • irregular or pounding heartbeat
  • loss of memory
  • mental depression
  • pain
  • pain in the arms or legs
  • pounding in the ears
  • rapid weight gain
  • sensation of spinning
  • slow or fast heartbeat
  • sore throat
  • sweating
  • tightness in chest
  • tingling of hands or feet
  • tingling, numbness, or prickly feelings
  • trouble in concentrating
  • troubled breathing
  • unusual weight gain or loss
  • vomiting
  • Anxiety
  • buzzing or ringing in the ears
  • changes in vision
  • fever
  • headache
  • joint pain
  • loss of bladder control
  • muscle cramps, pain, or spasms
  • nasal congestion
  • runny nose
  • sneezing
  • trouble with swallowing
  • unusual urges

If any of the following symptoms of overdose occur while taking ropinirole, get emergency help immediately:

Symptoms of overdose:
  • Agitation
  • grogginess
  • increase in unusual body movements, especially of the face or mouth
  • increased coughing
  • increased sweating
  • lack or loss of strength
  • nightmares

Minor Side Effects

Some ropinirole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Abnormal dreams
  • acid or sour stomach
  • back pain
  • belching
  • decrease in sexual desire or performance
  • difficulty having a bowel movement (stool)
  • dryness of mouth
  • flushing
  • general feeling of discomfort or illness
  • heartburn or gas
  • hot flashes
  • indigestion
  • loss of appetite
  • tremor
  • weight loss
  • yawning

For Healthcare Professionals

Applies to ropinirole: oral kit, oral tablet, oral tablet extended release


Parkinson's disease:
Very common (10% or more): Nausea (up to 60%), vomiting (up to 12%)
Common (1% to 10%): Dry mouth, abdominal pain, anorexia, dyspepsia, flatulence, constipation, diarrhea, dysphagia, increased saliva, heartburn

Restless Leg Syndrome:
Very common (10% or more): Nausea (up to 40%), vomiting (up to 12.9%)
Common (1% to 10%): Diarrhea, dyspepsia, dry mouth, abdominal pain upper
Uncommon (0.1% to 1%):[Ref]

Nervous system

Parkinson's disease
Very common (10% or more): Dizziness (40%), somnolence (40%), dyskinesia (34%), headache (17%)
Common (1% to 10%): Hyperkinesia, hypesthesia, hypokinesia, paresis, paresthesia, tremor
Uncommon (0.1% to 1%): Sudden onset of sleep, excessive daytime somnolence

Restless Leg Syndrome:
Very common (10% or more): Headache (up to 22.3%), somnolence (12%), dizziness (up to 12.9%)
Common (1% to 10%): Paresthesia, migraine, paradoxical augmentation and rebound of restless leg syndrome[Ref]


Parkinson's disease
Very common (10% or more): Hallucination (10%)
Common (1% to 10%): Amnesia, impaired concentration, confusion, amnesia, anxiety, abnormal dreaming, nervousness
Uncommon (0.1% to 1%): Psychotic reactions other than hallucinations, included delirium, delusions, paranoia
Frequency not reported: Aggression
Postmarketing reports: Impulse control disorders included pathological gambling and hypersexuality and increased libido

Restless Leg Syndrome:
Common (1% to 10%): Nervousness
Postmarketing reports: Impulse control disorders included pathological gambling and hypersexuality and increased libido[Ref]


Parkinson's disease:
Very common (10% or more): Syncope (up to 12%)
Common (1% to 10%): Hypertension, hypotension, orthostatic symptoms, chest pain, dependent edema, leg edema, flushing, extrasystoles, atrial fibrillation, palpitation, tachycardia, peripheral ischemia

Restless Leg Syndrome:
Common (1% to 10%): Syncope
Uncommon (0.1% to 1%): Orthostatic hypotension, peripheral edema
Frequency not reported: Hypotension[Ref]


Common (1% to 10%): Influenza, viral infection[Ref]


The most commonly reported adverse reaction reported in patients with early Parkinson's disease included nausea, somnolence, dizziness, syncope, asthenic conditions, viral infection, leg edema, vomiting, and dyspepsia. Among patients with advance Parkinson's disease, the more commonly reported adverse reactions included dyskinesia, somnolence, nausea, dizziness, confusion, hallucinations, sweating, and headache.

The most commonly reported adverse reactions in patients with restless legs syndrome included nausea, vomiting, somnolence, dizziness, and a asthenic condition.[Ref]


Parkinson's disease
Common (1% to 10%): Yawning, upper respiratory tract infection, dyspnea, bronchitis, pharyngitis, rhinitis, sinusitis

Restless Leg Syndrome:
Very common (10% or more): Upper respiratory infection (10.7%)
Common (1% to 10%): Nasopharyngitis, cough, nasal congestion, rhinitis, sinusitis[Ref]


Parkinson's disease:
Common (1% to 10%): Eye abnormality, abnormal vision, xerophthalmia, diplopia[Ref]


Parkinson's disease
Common (1% to 10%): Decreased weight[Ref]


Common (1% to 10%): Impotence, urinary tract infection, pyuria, urinary incontinence, urinary tract infection[Ref]


Asthenic conditions include asthenia, fatigue, and/or malaise[Ref]

Parkinson's disease
Very common (10% or more): Asthenic condition (16%)
Common (1% to 10%): Pain, vertigo

Restless Leg Syndrome:
Very common (10% or more): Fatigue (10.4%)
Common (1% to 10%): Asthenic condition, vertigo
Postmarketing reports:[Ref]


Common (1% to 10%): Arthralgia, arthritis, extremity pain, back pain, injury, myalgia[Ref]


Common (1% to 10%): Increased sweating[Ref]


Parkinson's disease
Common (1% to 10%): Anemia[Ref]


Parkinson's disease
Common (1% to 10%): Increased alkaline phosphatase
Frequency not reported: Increased liver enzymes[Ref]


Frequency not reported: Hypersensitivity reactions including urticarial, angioedema, rash, pruritus[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Requip (ropinirole)." SmithKline Beecham, Philadelphia, PA.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

It is possible that some side effects of Requip may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.