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Requip Side Effects

Generic name: ropinirole

Medically reviewed by Drugs.com. Last updated on May 5, 2022.

Note: This document contains side effect information about ropinirole. Some of the dosage forms listed on this page may not apply to the brand name Requip.

Summary

Common side effects of Requip include: syncope, dizziness, drowsiness, dyskinesia, fatigue, nausea, and viral infection. Other side effects include: asthenia, confusion, lower extremity edema, and diaphoresis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ropinirole: oral extended-release tablets, oral immediate-release tablets

Side effects include:

Patients with early parkinson disease receiving immediate-release tablets (without levodopa): Nausea, somnolence, dizziness, syncope, asthenic condition, viral infection, leg edema, vomiting, dyspepsia.

Patients with early parkinson disease receiving extended-release tablets: Nausea, somnolence, sudden onset of sleep, hypertension, headache, abdominal pain/discomfort, dizziness, constipation.

Patients with advanced parkinson disease receiving immediate-release tablets (with concomitant levodopa): Dyskinesia, somnolence, nausea, dizziness, confusion, hallucinations, sweating, headache.

Patients with advanced parkinson disease receiving extended-release tablets: Nausea, dyskinesia, dizziness, hallucinations.

Patients with RLS receiving immediate-release tablets: Nausea, somnolence, vomiting, dizziness, fatigue.

For Healthcare Professionals

Applies to ropinirole: oral kit, oral tablet, oral tablet extended release

Gastrointestinal

Parkinson's disease:

Very common (10% or more): Nausea (up to 60%), vomiting (up to 12%)

Common (1% to 10%): Dry mouth, abdominal pain, anorexia, dyspepsia, flatulence, constipation, diarrhea, dysphagia, increased saliva, heartburn

Restless Leg Syndrome:

Very common (10% or more): Nausea (up to 40%), vomiting (up to 12.9%)

Common (1% to 10%): Diarrhea, dyspepsia, dry mouth, abdominal pain upper

Uncommon (0.1% to 1%):[Ref]

Nervous system

Parkinson's disease

Very common (10% or more): Dizziness (40%), somnolence (40%), dyskinesia (34%), headache (17%)

Common (1% to 10%): Hyperkinesia, hypesthesia, hypokinesia, paresis, paresthesia, tremor

Uncommon (0.1% to 1%): Sudden onset of sleep, excessive daytime somnolence

Restless Leg Syndrome:

Very common (10% or more): Headache (up to 22.3%), somnolence (12%), dizziness (up to 12.9%)

Common (1% to 10%): Paresthesia, migraine, paradoxical augmentation and rebound of restless leg syndrome[Ref]

Psychiatric

Parkinson's disease

Very common (10% or more): Hallucination (10%)

Common (1% to 10%): Amnesia, impaired concentration, confusion, amnesia, anxiety, abnormal dreaming, nervousness

Uncommon (0.1% to 1%): Psychotic reactions other than hallucinations, included delirium, delusions, paranoia

Frequency not reported: Aggression

Postmarketing reports: Impulse control disorders included pathological gambling and hypersexuality and increased libido

Restless Leg Syndrome:

Common (1% to 10%): Nervousness

Postmarketing reports: Impulse control disorders included pathological gambling and hypersexuality and increased libido[Ref]

Cardiovascular

Parkinson's disease:

Very common (10% or more): Syncope (up to 12%)

Common (1% to 10%): Hypertension, hypotension, orthostatic symptoms, chest pain, dependent edema, leg edema, flushing, extrasystoles, atrial fibrillation, palpitation, tachycardia, peripheral ischemia

Restless Leg Syndrome:

Common (1% to 10%): Syncope

Uncommon (0.1% to 1%): Orthostatic hypotension, peripheral edema

Frequency not reported: Hypotension[Ref]

Immunologic

Common (1% to 10%): Influenza, viral infection[Ref]

General

The most commonly reported adverse reaction reported in patients with early Parkinson's disease included nausea, somnolence, dizziness, syncope, asthenic conditions, viral infection, leg edema, vomiting, and dyspepsia. Among patients with advance Parkinson's disease, the more commonly reported adverse reactions included dyskinesia, somnolence, nausea, dizziness, confusion, hallucinations, sweating, and headache.

The most commonly reported adverse reactions in patients with restless legs syndrome included nausea, vomiting, somnolence, dizziness, and a asthenic condition.[Ref]

Respiratory

Parkinson's disease

Common (1% to 10%): Yawning, upper respiratory tract infection, dyspnea, bronchitis, pharyngitis, rhinitis, sinusitis

Restless Leg Syndrome:

Very common (10% or more): Upper respiratory infection (10.7%)

Common (1% to 10%): Nasopharyngitis, cough, nasal congestion, rhinitis, sinusitis[Ref]

Ocular

Parkinson's disease:

Common (1% to 10%): Eye abnormality, abnormal vision, xerophthalmia, diplopia[Ref]

Metabolic

Parkinson's disease

Common (1% to 10%): Decreased weight[Ref]

Genitourinary

Common (1% to 10%): Impotence, urinary tract infection, pyuria, urinary incontinence, urinary tract infection[Ref]

Other

Parkinson's disease

Very common (10% or more): Asthenic condition (16%)

Common (1% to 10%): Pain, vertigo

Restless Leg Syndrome:

Very common (10% or more): Fatigue (10.4%)

Common (1% to 10%): Asthenic condition, vertigo

Postmarketing reports:[Ref]

Asthenic conditions include asthenia, fatigue, and/or malaise[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, arthritis, extremity pain, back pain, injury, myalgia[Ref]

Dermatologic

Common (1% to 10%): Increased sweating[Ref]

Hematologic

Parkinson's disease

Common (1% to 10%): Anemia[Ref]

Hepatic

Parkinson's disease

Common (1% to 10%): Increased alkaline phosphatase

Frequency not reported: Increased liver enzymes[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions including urticarial, angioedema, rash, pruritus[Ref]

References

1. "Product Information. Requip (ropinirole)." SmithKline Beecham (2001):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.