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Ramucirumab Side Effects

For the Consumer

Applies to ramucirumab: intravenous solution

Along with its needed effects, ramucirumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ramucirumab:

More common
  • Back pain or spasms
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • confusion
  • convulsions
  • decreased urine output
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • feeling unusually cold
  • headache
  • increased thirst
  • muscle pain or cramps
  • nausea or vomiting
  • nervousness
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • sweating
  • swelling of the face, ankles, or hands
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness
Less common
  • Abdominal or stomach pain, cramping, or burning
  • bleeding gums
  • bloody nose
  • cough
  • coughing up blood
  • difficulty with breathing or swallowing
  • dizziness
  • fever
  • inability to speak
  • increased menstrual flow or vaginal bleeding
  • low blood pressure or pulse
  • lower back or side pain
  • nosebleeds
  • pain in the chest, groin, or legs, especially calves of the legs
  • pain or discomfort in the arms, jaw, back, or neck
  • painful or difficult urination
  • pale skin
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • severe constipation
  • severe headaches of sudden onset
  • severe numbness, especially on one side of the face or body
  • slurred speech
  • sore throat
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • temporary blindness
  • ulcers, sores, or white spots in the mouth
  • unconsciousness
  • unusual bleeding or bruising
  • vomiting of material that looks like coffee grounds, severe and continuing

Some side effects of ramucirumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea

For Healthcare Professionals

Applies to ramucirumab: intravenous solution

Gastrointestinal

Very common (10% or more): Diarrhea (up to 32%), abdominal pain (up to 29%), stomatitis (up to 20%)
Common (1% to 10%): Gastrointestinal hemorrhage events, intestinal obstruction
Uncommon (0.1% to 1%): Gastrointestinal perforation[Ref]

Immunologic

Common (1% to 10%): Anti-ramucirumab antibodies
Uncommon (0.1% to 1%): Infusion related reactions[Ref]

Dermatologic

Common (1% to 10%): Rash[Ref]

Hematologic

Very common (10% or more): Neutropenia (up to 54%), leukopenia (34%), thrombocytopenia (up to 13%)[Ref]

Nervous system

Common (1% to 10%): Headache
Rare (less than 0.1%): Reversible Posterior Leukoencephalopathy Syndrome (RPLS)[Ref]

Renal

Very common (10% or more): Proteinuria (up to 17%)[Ref]

Cardiovascular

Very common (10% or more): Peripheral edema (up to 25%), hypertension (up to 25%)
Common (1% to 10%): Arterial thromboembolic events[Ref]

Metabolic

Very common (10% or more): Hypoalbuminemia (up to 11%)
Common (1% to 10%): Hyponatremia, hypokalemia[Ref]

Other

Very common (10% or more): Fatigue/asthenia (up to 57%)[Ref]

Respiratory

Very common (10% or more): Epistaxis (up to 31%)[Ref]

References

1. "Product Information. Cyramza (ramucirumab)." Eli Lilly and Company, Indianapolis, IN.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of ramucirumab may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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