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Ramucirumab Pregnancy and Breastfeeding Warnings

Ramucirumab is also known as: Cyramza

Medically reviewed on April 30, 2018

Ramucirumab Pregnancy Warnings

This drug should be used during pregnancy only if the benefit outweighs the risk.

US FDA pregnancy category: C

Comments:
-Based on its mechanism of action, this drug may cause fetal harm.
-If a patient becomes pregnant while taking this drug, she should be apprised of the potential hazard to a fetus.
-Female patients should be advised to avoid getting pregnant while receiving this drug and for at least 3 months after the last dose.
-Females of reproductive potential should be advised that this drug may impair fertility.

No animal studies have been conducted to evaluate the effect of the drug on reproduction and fetal development. There are no controlled data in human pregnancy.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

See references

Ramucirumab Breastfeeding Warnings

A decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Unknown
Excreted into animal milk: Unknown

Comments:
-The effects in the nursing infant are unknown.
-Breastfeeding should be delayed for at least three months after the last dose of this drug.

See references

References for pregnancy information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. "Product Information. Cyramza (ramucirumab)." Eli Lilly and Company, Indianapolis, IN.

References for breastfeeding information

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. "Product Information. Cyramza (ramucirumab)." Eli Lilly and Company, Indianapolis, IN.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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