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Qbrexza Side Effects

Generic name: glycopyrronium topical

Medically reviewed by Last updated on May 4, 2023.

Note: This document contains side effect information about glycopyrronium topical. Some dosage forms listed on this page may not apply to the brand name Qbrexza.

Applies to glycopyrronium topical: topical application pad.

Serious side effects of Qbrexza

Along with its needed effects, glycopyrronium topical (the active ingredient contained in Qbrexza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glycopyrronium topical:

Less common

  • Bigger, dilated, or enlarged pupils (black part of the eye)
  • blurred vision
  • different size pupils of the eyes
  • trouble in urinating

Incidence not known

  • Decrease in frequency of urination
  • decrease in urine volume
  • difficulty in emptying your bladder
  • difficulty in passing urine (dribbling)
  • painful urination

Other side effects of Qbrexza

Some side effects of glycopyrronium topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dry mouth
  • fever
  • headache
  • increased sensitivity of the eyes to light
  • muscle aches
  • pain in the mouth or throat
  • redness, burning, stinging, or itching of the skin
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

Less common

For Healthcare Professionals

Applies to glycopyrronium topical: topical pad.


Very common (10% or more): Local erythema (17%), local burning/stinging (14.1%)

Common (1% to 10%): Pruritus, application site pain, application site dermatitis, application site rash[Ref]


Very common (10% or more): Dry mouth (24.2%)

Common (1% to 10%): Constipation[Ref]


Common (1% to 10%): Nasopharyngitis, pharyngitis[Ref]


Common (1% to 10%): Urinary hesitation[Ref]


Common (1% to 10%): Oropharyngeal pain, nasal dryness, dry throat[Ref]


Common (1% to 10%): Dry skin[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Common (1% to 10%): Mydriasis, vision blurred, dry eye[Ref]

Frequently asked questions


1. Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc. 2018.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.