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Purixan Side Effects

Generic name: mercaptopurine

Medically reviewed by Drugs.com. Last updated on Jan 1, 2024.

Note: This document contains side effect information about mercaptopurine. Some dosage forms listed on this page may not apply to the brand name Purixan.

Applies to mercaptopurine: oral suspension, oral tablet.

Serious side effects of Purixan

Along with its needed effects, mercaptopurine (the active ingredient contained in Purixan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mercaptopurine:

More common

Less common

Incidence not known

Other side effects of Purixan

Some side effects of mercaptopurine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to mercaptopurine: oral suspension, oral tablet.

Hematologic

Very common (10% or more): Bone marrow suppression (e.g., anemia, leukopenia, thrombocytopenia) (more than 20%)[Ref]

Renal

Frequency not reported: Hyperuricemia[Ref]

Gastrointestinal

Common (1% to 10%): Stomatitis, diarrhea, vomiting, nausea

Uncommon (0.1% to 1%): Pancreatitis, oral ulceration

Very rare (less than 0.01%): Intestinal ulceration[Ref]

Hepatic

Common (1% to 10%): Biliary stasis, hepatotoxicity

Uncommon (0.1% to 1%): Hepatic necrosis

Frequency not reported: Hepatotoxicity[Ref]

Dermatologic

Uncommon (0.1% to 1%): Skin rash

Rare (less than 0.1%): Facial edema, alopecia

Frequency not reported: Photosensitivity reaction[Ref]

Genitourinary

Rare (less than 0.1%): Transient oligospermia[Ref]

Other

Frequency not reported: Fetotoxicity[Ref]

Oncologic

Rare (0.01% to 0.1%): Neoplasms including lymphoproliferative disorders, skin cancers (melanomas and non-melanomas), sarcomas (Kaposi's and non-Kaposi's), uterine cervical cancer in situ

Very rare (less than 0.01%): Secondary leukemia, myelodysplasia

Frequency not reported: Hepatosplenic T-cell lymphoma[Ref]

Immunologic

Uncommon (0.1% to 1%): Bacterial and viral infections, infections associated with neutropenia, drug fever

Frequency not reported: Immunosuppression, macrophage activation syndrome[Ref]

Metabolic

Common (1% to 10%): Anorexia

Frequency not reported: Hypoglycemia In patients with inflammatory bowel disease (IBD) (IBD is not an approved indication of this drug)[Ref]

Nervous system

Uncommon (0.1% to 1%): Arthralgia[Ref]

Cardiovascular

Postmarketing reports: Portal hypertension[Ref]

References

1. Product Information. Purixan (mercaptopurine). AnovoRx Distribution. 2019.

2. Product Information. Mercaptopurine (mercaptopurine). Mylan Pharmaceuticals Inc. 2019.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.