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Provayblue Side Effects

Generic Name: methylene blue

Note: This page contains side effects data for the generic drug methylene blue. It is possible that some of the dosage forms included below may not apply to the brand name Provayblue.

For the Consumer

Applies to methylene blue: intravenous solution

As well as its needed effects, methylene blue (the active ingredient contained in Provayblue) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking methylene blue, check with your doctor or nurse immediately:

Incidence not known:
  • Agitation
  • bluish-colored lips, fingernails, or palms
  • confusion
  • cough
  • dark urine
  • diarrhea
  • difficulty breathing
  • difficulty swallowing
  • dizziness or lightheadedness
  • fast heartbeat
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • overactive reflexes
  • pale skin
  • poor coordination
  • rapid heart rate
  • redness of the skin
  • restlessness
  • shivering
  • sore throat
  • sweating
  • talking or acting with excitement you cannot control
  • tightness in the chest
  • trembling or shaking
  • twitching
  • unusual bleeding or bruising
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking methylene blue, get emergency help immediately:

Symptoms of overdose:
  • Abdominal or stomach pain
  • bigger, dilated, or enlarged pupils (black part of the eye)
  • blue staining of the urine, skin, and mucous membranes
  • bluish-colored lips, fingernails, or palms
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • dark urine
  • difficulty breathing
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fear
  • fever
  • headache
  • increased sensitivity of the eyes to light
  • nausea
  • pale skin
  • rapid heart rate
  • rapid shallow breathing
  • shakiness in the legs, arms, hands, or feet
  • sore throat
  • tightness in the chest
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Minor Side Effects

Some methylene blue side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Change in taste
  • changes in skin color
  • feeling hot or cold
  • increased sweating
  • loss of taste
  • muscle or joint pain
  • pain at the infusion site
  • pain in the arms or legs
Less common:
  • Back pain
  • bruising
  • chills
  • general feeling of discomfort or illness
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle aches and pains
  • muscle spasm
  • runny nose
  • trouble sleeping

For Healthcare Professionals

Applies to methylene blue: compounding powder, injectable solution, intravenous solution, oral tablet

Cardiovascular

Cardiovascular side effects have included hypertension and precordial pain.[Ref]

References

1. "Product Information. Methylene Blue (methylene blue)." American Regent Laboratories Inc, Shirley, NY.

It is possible that some side effects of Provayblue may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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