Ponvory Side Effects

Generic name: ponesimod

Medically reviewed by Drugs.com. Last updated on Feb 12, 2025.

Note: This document provides detailed information about Ponvory Side Effects associated with ponesimod. Some dosage forms listed on this page may not apply specifically to the brand name Ponvory.

Applies to ponesimod: oral tablet.

Serious side effects of Ponvory

Along with its needed effects, ponesimod (the active ingredient contained in Ponvory) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ponesimod:

More common side effects

• agitation
• back pain
• bladder pain
• body aches or pain
• burning or stinging of the skin
• chest pain, discomfort, or tightness
• chills
• coma
• confusion
• cough
• cough producing mucus
• dark urine
• difficult, burning, or painful urination
• dizziness
• drowsiness
• ear congestion
• fever
• general feeling of illness
• hallucinations
• headache
• hoarseness
• irritability
• lightheadedness, dizziness, or fainting
• loss of appetite
• loss of voice
• lower back or side pain
• mood or mental changes
• nausea
• nervousness
• nosebleeds
• numbness or tingling in the face, arms, or legs
• painful cold sores or blisters on the lips, nose, or genitals
• pounding in the ears
• runny or stuffy nose
• seizures
• skin rash on the face, scalp, or stomach
• slow or irregular heartbeat
• stiff neck or back
• sneezing
• sore throat
• stomach pain
• tender, swollen glands in the neck
• trouble breathing
• trouble in swallowing
• unusual tiredness or weakness
• vision problems
• voice changes
• vomiting
• yellow eyes or skin

Less common side effects

• bloating or swelling of the face, arms, hands, lower legs, or feet
• blurred vision or other change in vision
• discouragement
• feeling of constant movement of self or surroundings
• feeling sad or empty
• headache, severe and throbbing
• loss of interest or pleasure
• painful blisters on the trunk of the body
• rapid weight gain
• sensation of spinning
• tingling of the hands or feet
• trouble concentrating
• trouble sleeping
• unusual weight gain or loss

Rare side effects

• change in size, shape, or color of the existing mole
• new mole
• mole that leaks fluid or bleeds
• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• shiny bump
• white, yellow, or waxy scar-like area

Other side effects of Ponvory

Some side effects of ponesimod may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• acid or sour stomach
• belching
• dry mouth
• heartburn
• indigestion
• pain in the arms or legs
• pain or tenderness around the eyes and cheekbones
• sleepiness or unusual drowsiness
• sleeplessness
• stomach discomfort or upset
• trouble sleeping

For healthcare professionals

Applies to ponesimod: oral tablet.

General adverse events

The most common adverse reactions occurring in more than 10% of patients taking this drug included upper respiratory infection (37%), increased hepatic transaminase (23%) and hypertension (up to 10%).^[Ref]

Cardiovascular

• Very common (10% or more): Hypertension (up to 10%)
• Common (1% to 10%): Bradycardia^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Basal cell carcinoma, melanoma
• Frequency not reported: Squamous cell carcinoma

Dermatologic

Gastrointestinal

• Common (1% to 10%): Dyspepsia, dry mouth

Genitourinary

• Common (1% to 10%): Urinary tract infection^[Ref]

Hematologic

• Common (1% to 10%): Increased C-reactive protein, lymphopenia^[Ref]

Hepatic

• Very common (10% or more): Increased hepatic transaminase (23%, includes ALT, AST)^[Ref]

Most patients with ALT increases of 3 times or greater than the upper limit of normal resolved on continued treatment with this drug within approximately 2-4 weeks.^[Ref]

Metabolic

• Common (1% to 10%): Hypercholesterolemia, hyperkalemia^[Ref]

Musculoskeletal

• Common (1% to 10%): Pain in extremity, joint swelling, back pain, ligament sprain, arthralgia^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, somnolence, migraine, seizures, hypoesthesia^[Ref]

Ocular

• Common (1% to 10%): Macular edema^[Ref]

Other

• Common (1% to 10%): Chest discomfort, fatigue, peripheral edema, pyrexia, vertigo, viral infection, herpes zoster^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia, depression, anxiety

Respiratory

• Very common (10% or more): Upper respiratory infection (37%)
• Common (1% to 10%): Cough, dyspnea, rhinitis, sinusitis
• Frequency not reported: Pneumonia^[Ref]

Upper respiratory infections included: nasopharyngitis, upper respiratory tract infection, pharyngitis, respiratory tract infection, bronchitis, respiratory tract infection viral, viral upper respiratory tract infection, tracheitis, and laryngitis.^[Ref]

Further information

Ponvory side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer