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Pneumococcal 20-valent conjugate vaccine Side Effects

Medically reviewed by Last updated on Sep 9, 2022.

Applies to pneumococcal 20-valent conjugate vaccine: intramuscular suspension.

Serious side effects

Along with its needed effects, pneumococcal 20-valent conjugate vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pneumococcal 20-valent conjugate vaccine:

More common

  • Fever

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • chest tightness
  • chills
  • cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble breathing
  • unusual tiredness or weakness

Other side effects

Some side effects of pneumococcal 20-valent conjugate vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty in moving
  • headache
  • muscle pain or stiffness
  • pain in the joints

For Healthcare Professionals

Applies to pneumococcal 20-valent conjugate vaccine: intramuscular suspension.


The most common adverse events were pain at the injection site, muscle pain, fatigue, headache, arthralgia, and injection site swelling.[Ref]


Very common (10% or more): Pain at the injection site (72.5% to 81.2% ), injection site swelling (8.8% to 11.6%)

Common (1% to 10%): Injection site redness

Postmarketing reports: Vaccination-site dermatitis, vaccination-site pruritus, vaccination-site urticaria[Ref]


Very common (10% or more): Muscle pain (49.8% to 66.6%), arthralgia (13.4% to 15.4%)[Ref]


Very common (10% or more): Fatigue (39.3% to 42.7%), use of antipyretic or pain medication (24.5% to 25.7%)

Common (1% to 10%): Fever[Ref]

Nervous system

Very common (10% or more): Headache (32.3% to 38.8%)[Ref]


Postmarketing reports: Anaphylactic/anaphylactoid reaction (including shock)[Ref]


Postmarketing reports: Angioneurotic edema, erythema multiforme[Ref]


Postmarketing reports: Lymphadenopathy localized to the region of the injection site[Ref]


1. "Product Information. Prevnar 20 (pneumococcal 20-valent conjugate vaccine)." Pfizer U.S. Pharmaceuticals Group (2021):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.