Skip to main content

Pneumococcal 20-valent conjugate vaccine

Generic name: pneumococcal 20-valent conjugate vaccine [ NOO-moe-KOK-al-20-VAY-lent-KON-joo-gate-VAX-een ]
Brand name: Prevnar 20
Dosage form: intramuscular suspension (-)
Drug class: Bacterial vaccines

Medically reviewed by on Mar 4, 2022. Written by Cerner Multum.

What is pneumococcal 20-valent conjugate vaccine?

Pneumococcal disease is a serious infection caused by a bacteria that can infect the sinuses, inner ear, lungs, blood, and brain. These conditions can be fatal.

Pneumococcal 20-valent conjugate vaccine is used in adults to help prevent disease caused by pneumococcal bacteria. This vaccine contains 20 different types of pneumococcal bacteria.

This vaccine helps your body develop immunity to the disease, but will not treat an active infection you already have.

Like any vaccine, pneumococcal 20-valent conjugate vaccine may not provide protection from disease in every person.


You should not receive this vaccine if you ever had a severe allergic reaction to a pneumococcal or diphtheria toxoid vaccine.

Before taking this medicine

You should not receive this vaccine if you ever had a severe allergic reaction to a pneumococcal or diphtheria toxoid vaccine.

Tell the vaccination provider if you have:

  • a weak immune system (caused by disease or by using certain medicine); or

  • if you are receiving radiation or chemotherapy.

You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

Tell the vaccination provider if you are pregnant or breastfeeding.

How should I take pneumococcal 20-valent conjugate vaccine?

This vaccine is given as an injection (shot) into a muscle.

Pneumococcal 20-valent conjugate vaccine is usually given as 1 shot.

What happens if I miss a dose?

Pneumococcal 20-valent conjugate vaccine is used as a single dose and does not have a booster schedule.

What happens if I overdose?

An overdose of this vaccine is unlikely to occur.

What should I avoid while taking pneumococcal 20-valent conjugate vaccine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Pneumococcal 20-valent conjugate vaccine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Keep track of all side effects you have. If you ever need another pneumococcal 20-valent conjugate vaccine, you will need to tell the vaccination provider if the previous shot caused any side effects.

Becoming infected with pneumococcal disease is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is low.

Common side effects of pneumococcal 20-valent conjugate vaccine may include:

  • pain or swelling where a shot was given;

  • muscle or joint pain;

  • headache; or

  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

Pneumococcal 20-valent conjugate vaccine dosing information

Usual Adult Dose for Pneumococcal Disease Prophylaxis:

0.5 mL IM once

-Use for the prevention of pneumonia caused by S. pneumoniae serotypes 8, 10A, 11A, 12F, 15B, 22F, and 33F is approved under accelerated approval based on immune responses as measured by opsonophagocytic activity (OPA) assay; continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

Use: Active immunization for prevention of pneumonia and invasive disease caused by S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 8, 9V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F

What other drugs will affect pneumococcal 20-valent conjugate vaccine?

Tell the vaccination provider if you have recently received drugs or treatments that can weaken the immune system, including:

This list is not complete. Other drugs may affect pneumococcal 20-valent conjugate vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about pneumococcal 20-valent conjugate vaccine

Patient resources

Other brands

Prevnar 20

Related treatment guides

Further information

  • Your vaccination provider, pharmacist, or doctor can provide more information about this vaccine. Additional information is available from your local health department or the Centers for Disease Control and Prevention.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.