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Pneumococcal 13-valent conjugate vaccine

Generic name: pneumococcal 13-valent conjugate vaccine [ NOO-moe-KOK-al-13-VAY-lent-KON-joo-gate-VAX-een ]
Brand name: Prevnar 13
Dosage form: intramuscular suspension (-)
Drug class: Bacterial vaccines

Medically reviewed by on Sep 25, 2023. Written by Cerner Multum.

What is pneumococcal 13-valent conjugate vaccine?

Pneumococcal disease is a serious infection caused by a bacteria that can infect the sinuses, inner ear, lungs, blood, and brain. These conditions can be fatal.

Pneumococcal 13-valent vaccine is used to help prevent disease caused by pneumococcal bacteria. This vaccine contains 13 different types of pneumococcal bacteria.

Pneumococcal 13-valent vaccine is for use in adults and children at least 6 weeks old.

This vaccine helps your body develop immunity to the disease, but will not treat an active infection you already have.

Like any vaccine, pneumococcal 13-valent vaccine may not provide protection from disease in every person.

This vaccine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You should not receive a booster vaccine if you had a life threatening allergic reaction after the first shot.

Keep track of all side effects you have. If you need a booster dose, you will need to tell the vaccination provider if the previous shot caused any side effects.

Becoming infected with pneumococcal disease is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is low.

Pneumococcal 13-valent conjugate vaccine may cause serious side effects. Call your doctor at once if you have:

Common side effects include

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.


You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Before taking this medicine

You should not receive this vaccine if you ever had a severe allergic reaction to a pneumococcal or diphtheria toxoid vaccine.

Tell the vaccination provider if you or the child has:

Before your child receives this vaccine, tell your doctor if the child was born prematurely.

You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

Tell the vaccination provider if you are pregnant or breastfeeding.

How is this vaccine given?

This vaccine is given as an injection (shot) into a muscle.

For infants and toddlers, the pneumococcal 13-valent vaccine is given in a series of shots. The first shot is usually given when the child is 6 weeks to 2 months old. The booster shots are then given at 4 months, 6 months, and 12 to 15 months of age.

If your child is 7 months to 5 years old, he or she can still receive this vaccine on the following schedule:

The timing of this vaccination is very important for it to be effective. Your child's individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by your local health department.

For adults and children older than 5 years, this vaccine is usually given as one shot.

Be sure to keep your child on a regular schedule for other immunizations such as diphtheria, tetanus, pertussis (whooping cough), hepatitis, and varicella (chicken pox). Your doctor or state health department can provide you with a recommended immunization schedule.

Pneumococcal 13-valent conjugate vaccine dosing information

Usual Adult Dose for Pneumococcal Disease Prophylaxis:

0.5 mL, IM, once

Usual Pediatric Dose for Pneumococcal Disease Prophylaxis:

6 weeks to 5 years:
4 doses: 0.5 mL, IM, at 2 months, 4 months, 6 months, and 12 to 15 months

Unvaccinated Children 7 months through 5 years:

-Aged 7 to 11 months at first dose: a total of three 0.5 mL doses, IM
--Give the first 2 doses at least 4 weeks apart.
--Give the third dose after the one year birthday, at least 2 months after the second dose.

-Aged 12 to 23 months at first dose: a total of two 0.5 mL doses, IM
--Give the doses at least 2 months apart.

-Aged 24 months to 5 years at first dose: one 0.5 mL dose, IM

6 to 17 years:
0.5 mL, IM, once, at least 8 weeks after any previous pneumococcal vaccine

What happens if I miss a dose?

Contact your vaccination provider if you miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.

Be sure to receive all recommended doses of this vaccine or you may not be fully protected against disease.

What happens if I overdose?

An overdose of this vaccine is unlikely to occur.

What should I avoid before or after receiving this vaccine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect this vaccine?

Before receiving this vaccine, tell your vaccination provider about all other vaccines you have recently received.

Also tell the vaccination provider if you have recently received drugs or treatments that can weaken the immune system, including:

This list is not complete. Other drugs may affect pneumococcal 13-valent conjugate vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.