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Pneumococcal 13-valent vaccine Side Effects

For the Consumer

Applies to pneumococcal 13-valent vaccine: intramuscular suspension

As well as its needed effects, pneumococcal 13-valent vaccine may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pneumococcal 13-valent vaccine, check with your doctor or nurse immediately:

More common:
  • Fever
  • Chest pain
  • chills
  • coughing, wheezing, or shortness of breath
  • difficult or labored breathing
  • difficulty with swallowing
  • fast heartbeat
  • noisy breathing
  • seizures
  • skin itching, rash, or redness
  • sneezing
  • sore throat
  • swelling of the face, throat, or tongue
  • tightness in the chest
Incidence not known:
  • Bladder pain
  • blistering, peeling, or loosening of the skin
  • bloody or cloudy urine
  • bluish lips or skin
  • body aches or pain
  • choking
  • confusion
  • decreased urine output
  • diarrhea
  • difficult, burning, or painful urination
  • dilated neck veins
  • ear congestion
  • extreme fatigue
  • fainting
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • hives
  • irregular breathing
  • irregular heartbeat
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • muscle aches and pains
  • nasal congestion
  • nausea
  • not breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid, shallow breathing
  • red, irritated eyes
  • runny nose
  • shivering
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Minor Side Effects

Some pneumococcal 13-valent vaccine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Decreased appetite
  • decreased sleep
  • irritability
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • Abdominal or stomach pain
  • crying
  • hives or welts
  • weakness
Incidence not known:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, rash, redness, scarring, soreness, stinging, tingling, ulceration, or warmth at the injection site
  • burning, dry, or itching eyes
  • eye discharge or excessive tearing
  • pain
  • stomach cramps
  • tenderness

For Healthcare Professionals

Applies to pneumococcal 13-valent vaccine: intramuscular suspension


The most common adverse events were local reactions, irritability, sleep changes, decreased appetite, and fever. Musculoskeletal events were common in adults.[Ref]


Very common (10% or more): Local tenderness (89%), local redness (70%), local swelling (44.5%), induration (32.6%)
Uncommon (0.1% to 1%): Lymphadenopathy localized to the region of the vaccination site
Postmarketing reports: Vaccination site dermatitis, vaccination site urticaria, vaccination site pruritus[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reaction (including face edema, dyspnea, and bronchospasm)
Postmarketing reports: Anaphylactic/anaphylactoid reaction including shock[Ref]

Nervous system

Very common (10% or more): Headache (81.4%)
Uncommon (0.1% to 1%): Seizures (including febrile seizures)
Rare (less than 0.1%): Hypotonic-hyporesponsive episode[Ref]


Very common (10% or more): Fever (43%), fatigue
Uncommon (0.1% to 1%): Crying
Rare (less than 0.1%): Sudden infant death syndrome[Ref]


Very common (10% or more): New muscle pain (82%), aggravated muscle pain (55.9%), new joint pain (41.7%), chills (38.1%) aggravated joint pain (28.6%)[Ref]


Very common (10% or more): Decreased appetite (51%)[Ref]


Very common (10% or more): Irritability (85.6%), increased sleep (71.5%), decreased sleep (45.6%)[Ref]


Very common (10% or more): Vomiting (15%), diarrhea
Uncommon (0.1% to 1%): Gastroenteritis[Ref]


Common (1% to 10%): Hives (urticaria), rash
Postmarketing reports: Flushing, angioedema, erythema multiforme[Ref]


Uncommon (0.1% to 1%): Bronchiolitis, pneumonia[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Prevnar 13 (pneumococcal 13-valent vaccine)." Wyeth Laboratories, Philadelphia, PA.

It is possible that some side effects of pneumococcal 13-valent vaccine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.