Pegaspargase Side Effects
Medically reviewed by Drugs.com. Last updated on Feb 22, 2021.
For the Consumer
Applies to pegaspargase: parenteral injection
Side effects include:
Grade 3 or 4 reactions: Hypoalbuminemia, elevated serum aminotransferase concentrations, febrile neutropenia, hypertriglyceridemia, hyperglycemia, hyperbilirubinemia, pancreatitis, clotting study abnormalities, embolic and thrombotic events, hypersensitivity reactions.
No apparent difference in adverse effects following IV versus IM administration.
For Healthcare Professionals
Applies to pegaspargase: injectable solution
The most commonly reported side effects were elevated transaminases and clinical allergic reactions to asparaginase (including bronchospasm, hypotension, laryngeal edema, local erythema or swelling, systemic rash, and urticaria).[Ref]
Common (1% to 10%): Central nervous system thrombosis/hemorrhage, seizure, peripheral motor neuropathy, syncope
Rare (less than 0.1%): Posterior reversible leukoencephalopathy syndrome
Frequency not reported: Somnolence, tremor[Ref]
Common (1% to 10%): Thrombosis, embolism[Ref]
Rare (less than 0.1%): Pancreatitis necrotizing, pancreatitis hemorrhagic
Frequency not reported: Pancreatic pseudocyst, parotitis[Ref]
Very common (10% or more): Febrile neutropenia
Common (1% to 10%): Coagulopathy (prolonged prothrombin time or partial thromboplastin time; or hypofibrinogenemia), anemia
Frequency not reported: Bone marrow failure[Ref]
Very common (10% or more): Elevated transaminases
Common (1% to 10%): Hyperbilirubinemia, hepatotoxicity, fatty liver
Common (1% to 10%): Hyperglycemia, weight decreased, decreased appetite
Common (1% to 10%): Pain in extremities[Ref]
Frequency not reported: Confusion[Ref]
Common (1% to 10%): Hypoxia[Ref]
Frequency not reported: Pyrexia[Ref]
Frequency not reported: Acute renal failure[Ref]
Very common (10% or more): Rash
Frequently asked questions
More about pegaspargase
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 1 Review
- Drug class: miscellaneous antineoplastics
- Other brands
Related treatment guides
1. "Product Information. Oncaspar (pegaspargase)." Rhone-Poulenc Rorer, Collegeville, PA.
Some side effects may not be reported. You may report them to the FDA.