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Pegaspargase Side Effects

Medically reviewed by Drugs.com. Last updated on Feb 15, 2024.

Applies to pegaspargase: parenteral injection.

Side effects include:

Grade 3 or 4 reactions: Hypoalbuminemia, elevated serum aminotransferase concentrations, febrile neutropenia, hypertriglyceridemia, hyperglycemia, hyperbilirubinemia, pancreatitis, clotting study abnormalities, embolic and thrombotic events, hypersensitivity reactions.

No apparent difference in adverse effects following IV versus IM administration.

For healthcare professionals

Applies to pegaspargase: injectable solution.

General

The most commonly reported side effects were elevated transaminases and clinical allergic reactions to asparaginase (including bronchospasm, hypotension, laryngeal edema, local erythema or swelling, systemic rash, and urticaria).[Ref]

Hypersensitivity

Nervous system

Cardiovascular

Gastrointestinal

Hematologic

Hepatic

Metabolic

Immunologic

Musculoskeletal

Psychiatric

Respiratory

Other

Renal

Dermatologic

References

1. (2001) "Product Information. Oncaspar (pegaspargase)." Rhone Poulenc Rorer

Frequently asked questions

Further information

Pegaspargase side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.