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Pediazole Side Effects

Generic Name: erythromycin / sulfisoxazole

Note: This page contains side effects data for the generic drug erythromycin / sulfisoxazole. It is possible that some of the dosage forms included below may not apply to the brand name Pediazole.

Applies to erythromycin / sulfisoxazole: oral powder for suspension

As well as its needed effects, erythromycin / sulfisoxazole may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking erythromycin / sulfisoxazole, check with your doctor immediately:

More common:
  • Itching
  • skin rash
Less common:
  • Aching of joints and muscles
  • difficulty in swallowing
  • nausea or vomiting
  • pale skin
  • redness, blistering, peeling, or loosening of skin
  • skin rash
  • sore throat and fever
  • stomach pain, severe
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin
  • Blood in urine
  • dark or amber urine
  • irregular or slow heartbeat
  • temporary loss of hearing (with kidney disease and high doses)
  • lower back pain
  • pain or burning while urinating
  • pale stools
  • recurrent fainting
  • severe stomach pain
  • swelling of front part of neck

Severity: Moderate

If any of the following side effects occur while taking erythromycin / sulfisoxazole, check with your doctor or nurse as soon as possible:

More common:
  • Increased sensitivity to sunlight

Minor Side Effects

Some erythromycin / sulfisoxazole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abdominal or stomach cramping and discomfort
  • diarrhea
  • headache
  • loss of appetite
  • nausea or vomiting
Less common:
  • Sore mouth or tongue

It is possible that some side effects of Pediazole may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Pediazole (erythromycin / sulfisoxazole)

Consumer resources

Other brands: Eryzole

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.