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Panobinostat Side Effects

In Summary

Commonly reported side effects of panobinostat include: severe diarrhea, pneumonia, severe infection, severe neutropenia, cardiac arrhythmia, abnormal t waves on ecg, depression of st segment on ecg, diarrhea, neutropenia, and thrombocytopenia. Other side effects include: sepsis, and hemorrhage. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to panobinostat: oral capsule

Along with its needed effects, panobinostat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking panobinostat:

More common
  • Abdominal or stomach pain or tenderness
  • black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • clay colored stools
  • confusion
  • cough or sore throat
  • dark or bloody urine
  • decreased appetite
  • decreased frequency or amount of urine
  • dizziness, faintness, or lightheadedness especially when getting up suddenly from a lying or sitting position
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever, chills, or sweating
  • headache
  • increased thirst
  • itching or skin rash
  • loss of appetite
  • lower back or side pain
  • muscle spasms or twitching
  • nausea or vomiting
  • nervousness
  • painful or difficult urination
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid breathing
  • seizures
  • severe diarrhea
  • slow or fast heartbeat
  • swelling of the face, fingers, feet, or lower legs
  • tingling of the hands or feet
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • yellow eyes or skin
Less common

Some side effects of panobinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching or passing gas
  • change or loss in taste
  • depressed mood
  • dry mouth
  • hair loss
  • heartburn or indigestion
  • hoarseness or husky voice
  • fatigue or feeling lethargic
  • redness of the skin

For Healthcare Professionals

Applies to panobinostat: oral capsule


Very common (10% or more): Diarrhea (68%), nausea (36%), vomiting (26%)
Common (1% to 10%): Abdominal pain, dyspepsia, gastritis, cheilitis, abdominal distension, dry mouth, flatulence, colitis, gastrointestinal pain


Very common (10% or more): T-wave abnormalities (40%), ST-segment depression (22%), arrhythmia (12%)
Common (1% to 10%): Palpitations, hypotension, hypertension, orthostatic hypotension
Uncommon (0.1% to 1%): Cardiac ischemic events[Ref]


Very common (10% or more): Thrombocytopenia (97%), lymphopenia (82%), leukopenia (81%), neutropenia (75%), anemia (62%)
Common (1% to 10%): Grade 3/4 hemorrhage


Very common (10% or more): Severe infections (31%)
Common (1% to 10%): Hepatitis B


Common (1% to 10%): Increased blood alkaline phosphatase
Frequency not reported: Hepatic dysfunction (primarily aminotransferase and total bilirubin elevations)


Very common (10% or more): Hypocalcemia (67%), hypoalbuminemia (63%), hypophosphatemia (63%), hypokalemia (52%), hyponatremia (49%), hyperphosphatemia (29%), decreased appetite (28%), hypermagnesemia (27%), hyperbilirubinemia (21%), decreased weight (12%)
Common (1% to 10%): Hyperglycemia, dehydration, fluid retention, hypomagnesemia


Common (1% to 10%): Skin lesions, rash, erythema


Common (1% to 10%): Hypothyroidism


Common (1% to 10%): Urinary incontinence, hyperuricemia


Common (1% to 10%): Joint swelling

Nervous system

Common (1% to 10%): Dizziness, headache, syncope, tremor, dysgeusia


Very common (10% or more): Fatigue (60%), peripheral edema (29%), pyrexia (26%)
Common (1% to 10%): Chills


Common (1% to 10%): Insomnia


Very common (10% or more): Increased blood creatinine (41%)
Common (1% to 10%): Renal failure, increased blood urea, decreased glomerular filtration rate


Common (1% to 10%): Cough, dyspnea, respiratory failure, rales, wheezing


1. "Product Information. Farydak (panobinostat)." Novartis Pharmaceuticals, East Hanover, NJ.

Some side effects of panobinostat may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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