Panobinostat Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 29, 2024.

Applies to panobinostat: oral capsule.

Precautions

It is very important that your doctor check your progress while you are using this medicine to see if it is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control (eg, condoms) to keep from getting pregnant during therapy and for 1 month after the last dose (for sexually-active females), and for 3 months after the last dose (for sexually-active men). If you think you or your partner have become pregnant while using the medicine, tell your doctor right away.

Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Panobinostat can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
• Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
• Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
• Avoid contact sports or other situations where bruising or injury could occur.

This medicine may increase your risk of developing infections. Avoid being near people who are sick or have infections while you are using this medicine. Wash your hands often. Tell your doctor if you have any kind of infection before you start using this medicine. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of panobinostat

Along with its needed effects, panobinostat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking panobinostat:

Other side effects of panobinostat

Some side effects of panobinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to panobinostat: oral capsule.

Gastrointestinal adverse events

• Very common (10% or more): Diarrhea (68%), nausea (36%), vomiting (26%)
• Common (1% to 10%): Abdominal pain, dyspepsia, gastritis, cheilitis, abdominal distension, dry mouth, flatulence, colitis, gastrointestinal pain

Cardiovascular

• Very common (10% or more): T-wave abnormalities (40%), ST-segment depression (22%), arrhythmia (12%)
• Common (1% to 10%): Palpitations, hypotension, hypertension, orthostatic hypotension
• Uncommon (0.1% to 1%): Cardiac ischemic events^[Ref]

Hematologic

• Very common (10% or more): Thrombocytopenia (97%), lymphopenia (82%), leukopenia (81%), neutropenia (75%), anemia (62%)
• Common (1% to 10%): Grade 3/4 hemorrhage

Immunologic

• Very common (10% or more): Severe infections (31%)
• Common (1% to 10%): Hepatitis B

Hepatic

• Common (1% to 10%): Increased blood alkaline phosphatase
• Frequency not reported: Hepatic dysfunction (primarily aminotransferase and total bilirubin elevations)

Metabolic

• Very common (10% or more): Hypocalcemia (67%), hypoalbuminemia (63%), hypophosphatemia (63%), hypokalemia (52%), hyponatremia (49%), hyperphosphatemia (29%), decreased appetite (28%), hypermagnesemia (27%), hyperbilirubinemia (21%), decreased weight (12%)
• Common (1% to 10%): Hyperglycemia, dehydration, fluid retention, hypomagnesemia

Dermatologic

• Common (1% to 10%): Skin lesions, rash, erythema

Endocrine

• Common (1% to 10%): Hypothyroidism

Genitourinary

• Common (1% to 10%): Urinary incontinence, hyperuricemia

Musculoskeletal

• Common (1% to 10%): Joint swelling

Nervous system

• Common (1% to 10%): Dizziness, headache, syncope, tremor, dysgeusia

Other

• Very common (10% or more): Fatigue (60%), peripheral edema (29%), pyrexia (26%)
• Common (1% to 10%): Chills

Psychiatric

• Common (1% to 10%): Insomnia

Renal

• Very common (10% or more): Increased blood creatinine (41%)
• Common (1% to 10%): Renal failure, increased blood urea, decreased glomerular filtration rate

Respiratory

• Common (1% to 10%): Cough, dyspnea, respiratory failure, rales, wheezing

See also:

Further information

Panobinostat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer