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Panobinostat Side Effects

In Summary

Commonly reported side effects of panobinostat include: severe diarrhea, pneumonia, severe infection, severe neutropenia, cardiac arrhythmia, abnormal t waves on ecg, depression of st segment on ecg, diarrhea, neutropenia, and thrombocytopenia. Other side effects include: sepsis, and hemorrhage. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to panobinostat: oral capsule

As well as its needed effects, panobinostat may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking panobinostat, check with your doctor immediately:

More common:
  • Abdominal or stomach pain or tenderness
  • black, tarry stools
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • clay colored stools
  • confusion
  • cough or sore throat
  • dark or bloody urine
  • decreased appetite
  • decreased frequency or amount of urine
  • dizziness, faintness, or lightheadedness especially when getting up suddenly from a lying or sitting position
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever, chills, or sweating
  • headache
  • increased thirst
  • itching or skin rash
  • loss of appetite
  • lower back or side pain
  • muscle spasms or twitching
  • nausea or vomiting
  • nervousness
  • painful or difficult urination
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid breathing
  • seizures
  • severe diarrhea
  • slow or fast heartbeat
  • swelling of the face, fingers, feet, or lower legs
  • tingling of the hands or feet
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • yellow eyes or skin
Less common:
  • Chest pain or discomfort
  • coughing up blood
  • difficulty with swallowing
  • increased menstrual flow or vaginal bleeding
  • nosebleeds
  • pain in the shoulders, arms, jaw, or neck
  • paralysis

Minor Side Effects

Some panobinostat side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • belching or passing gas
  • change or loss in taste
  • depressed mood
  • dry mouth
  • hair loss
  • heartburn or indigestion
  • hoarseness or husky voice
  • fatigue or feeling lethargic
  • redness of the skin

For Healthcare Professionals

Applies to panobinostat: oral capsule

Gastrointestinal

Very common (10% or more): Diarrhea (68%), nausea (36%), vomiting (26%)
Common (1% to 10%): Abdominal pain, dyspepsia, gastritis, cheilitis, abdominal distension, dry mouth, flatulence, colitis, gastrointestinal pain

Cardiovascular

Very common (10% or more): T-wave abnormalities (40%), ST-segment depression (22%), arrhythmia (12%)
Common (1% to 10%): Palpitations, hypotension, hypertension, orthostatic hypotension
Uncommon (0.1% to 1%): Cardiac ischemic events[Ref]

Hematologic

Very common (10% or more): Thrombocytopenia (97%), lymphopenia (82%), leukopenia (81%), neutropenia (75%), anemia (62%)
Common (1% to 10%): Grade 3/4 hemorrhage

Immunologic

Very common (10% or more): Severe infections (31%)
Common (1% to 10%): Hepatitis B

Hepatic

Common (1% to 10%): Increased blood alkaline phosphatase
Frequency not reported: Hepatic dysfunction (primarily aminotransferase and total bilirubin elevations)

Metabolic

Very common (10% or more): Hypocalcemia (67%), hypoalbuminemia (63%), hypophosphatemia (63%), hypokalemia (52%), hyponatremia (49%), hyperphosphatemia (29%), decreased appetite (28%), hypermagnesemia (27%), hyperbilirubinemia (21%), decreased weight (12%)
Common (1% to 10%): Hyperglycemia, dehydration, fluid retention, hypomagnesemia

Dermatologic

Common (1% to 10%): Skin lesions, rash, erythema

Endocrine

Common (1% to 10%): Hypothyroidism

Genitourinary

Common (1% to 10%): Urinary incontinence, hyperuricemia

Musculoskeletal

Common (1% to 10%): Joint swelling

Nervous system

Common (1% to 10%): Dizziness, headache, syncope, tremor, dysgeusia

Other

Very common (10% or more): Fatigue (60%), peripheral edema (29%), pyrexia (26%)
Common (1% to 10%): Chills

Psychiatric

Common (1% to 10%): Insomnia

Renal

Very common (10% or more): Increased blood creatinine (41%)
Common (1% to 10%): Renal failure, increased blood urea, decreased glomerular filtration rate

Respiratory

Common (1% to 10%): Cough, dyspnea, respiratory failure, rales, wheezing

References

1. "Product Information. Farydak (panobinostat)." Novartis Pharmaceuticals, East Hanover, NJ.

It is possible that some side effects of panobinostat may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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