Onpattro Side Effects

Generic name: patisiran

Medically reviewed by Drugs.com. Last updated on Nov 8, 2023.

Note: This document contains side effect information about patisiran. Some dosage forms listed on this page may not apply to the brand name Onpattro.

Applies to patisiran: intravenous solution.

Serious side effects of Onpattro

Along with its needed effects, patisiran (the active ingredient contained in Onpattro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking patisiran:

More common

Back pain
body aches or pain
chest tightness
chills
cough
difficulty in breathing
ear congestion
feeling of warmth
fever
headache
loss of voice
nasal congestion
nausea
redness of the face, neck, arms, and occasionally, upper chest
runny nose
sneezing
sore throat
unusual tiredness or weakness
vomiting

Less common

Blurred vision
chest pain
cough producing mucus
dizziness
dry eye
fainting
pounding, slow heartbeat
seeing floating dark spots or material before the eyes

Rare

Blistering, crusting, irritation, itching, or reddening of the skin burning, pain, redness, or swelling at the injection site
changes in skin color, pain, tenderness, or swelling of the foot or leg
cracked, dry, scaly skin

Other side effects of Onpattro

Some side effects of patisiran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Belching
feeling of constant movement of self or surroundings
heartburn
indigestion
muscle spasms
sensation of spinning
stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to patisiran: intravenous solution.

General

The most common adverse reactions were upper respiratory tract infections, infusion-related reactions and peripheral edema.^[Ref]

Cardiovascular

There were 3.7% of patients with atrioventricular heart block, of which three cases were complete AV block.^[Ref]

Common (1% to 10%): Atrioventricular (AV) heart block^[Ref]

Respiratory

Upper respiratory infections included nasopharyngitis, upper respiratory tract infection, respiratory tract infection, pharyngitis, rhinitis, sinusitis, viral upper respiratory tract infection, and upper respiratory tract congestion.^[Ref]

Very common (10% or more): Upper respiratory infection (29%)

Common (1% to 10%): Dyspnea, bronchitis^[Ref]

Ocular

Common (1% to 10%): Dry eye, blurred vision, vitreous floaters^[Ref]

Musculoskeletal

Common (1% to 10%): Muscle spasms, arthralgia^[Ref]

Other

Common (1% to 10%): Vertigo^[Ref]

Dermatologic

Common (1% to 10%): Erythema^[Ref]

Gastrointestinal

Common (1% to 10%): Dyspepsia^[Ref]

Immunologic

Among patients who experienced infusion-related reactions (IRR), up to 79% occurred within the first two infusions and the frequency decreased over time. IRR led to infusion interruption in 5% of patients and resulted in permanent discontinuation in less than 1%.

There was no evidence that anti-drug antibodies influenced the clinical efficacy, safety, pharmacokinetic or pharmacodynamic profiles of this drug; however, the data are limited.^[Ref]

Very common (10% or more): Infusion-related reactions (up to 19%)

Common (1% to 10%): Antibody formation^[Ref]