Skip to main content

Onpattro: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on March 27, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Onpattro (patisiran) contains small lipid nanoparticles that contain small interfering RNAs that break down deposits of transthyretin - a protein that is increased by a rare condition called hereditary transthyretin-mediated amyloidosis (hATTR). Onpattro is infused by a healthcare provider every 3 weeks and is effective at stopping or reversing the progression of nerve damage associated with hATTR. Infusion site reactions and upper respiratory tract infections are the most common side effects reported.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Onpattro may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Onpattro. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

No formal clinical drug interaction studies have been performed with Onpattro and the product information does not list any interactions. Onpattro does not inhibit or induce any cytochrome P450 enzymes or transporters at clinically relevant plasma concentrations and is not a substrate of cytochrome P450 enzymes.

Onpattro is not expected to cause drug-drug interactions or to be affected by inhibitors or inducers of cytochrome P450 enzymes.

Always refer to the prescribing information for Onpattro for any interaction updates.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Onpattro only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: March 27, 2023.