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Oncaspar Side Effects

Generic Name: pegaspargase

Note: This document contains side effect information about pegaspargase. Some of the dosage forms listed on this page may not apply to the brand name Oncaspar.

For the Consumer

Applies to pegaspargase: parenteral injection

Side effects include:

Hypersensitivity reactions, coagulopathy, hyperglycemia, elevated serum transaminase concentrations, hyperbilirubinemia, pancreatitis, CNS thrombosis. No apparent difference in adverse effects following IV versus IM administration.

For Healthcare Professionals

Applies to pegaspargase: injectable solution

General

The most commonly reported side effects were elevated transaminases and clinical allergic reactions to asparaginase (including bronchospasm, hypotension, laryngeal edema, local erythema or swelling, systemic rash, and urticaria).[Ref]

Hypersensitivity

Very common (10% or more): Hypersensitivity, urticaria, anaphylactic reaction[Ref]

Nervous system

Common (1% to 10%): Central nervous system thrombosis/hemorrhage, seizure, peripheral motor neuropathy, syncope

Rare (less than 0.1%): Posterior reversible leukoencephalopathy syndrome

Frequency not reported: Somnolence, tremor[Ref]

Cardiovascular

Common (1% to 10%): Thrombosis, embolism[Ref]

Gastrointestinal

Very common (10% or more): Pancreatitis, diarrhea, abdominal pain, nausea

Common (1% to 10%): Vomiting, stomatitis, ascites

Rare (less than 0.1%): Pancreatitis necrotizing, pancreatitis hemorrhagic

Frequency not reported: Pancreatic pseudocyst, parotitis[Ref]

Hematologic

Very common (10% or more): Febrile neutropenia

Common (1% to 10%): Coagulopathy (prolonged prothrombin time or partial thromboplastin time; or hypofibrinogenemia), anemia

Frequency not reported: Bone marrow failure[Ref]

Hepatic

Very common (10% or more): Elevated transaminases

Common (1% to 10%): Hyperbilirubinemia, hepatotoxicity, fatty liver

Rare (0.01% to 0.1%): Hepatic necrosis, jaundice, cholestasis, hepatic failure[Ref]

Metabolic

Common (1% to 10%): Hyperglycemia, weight decreased, decreased appetite

Frequency not reported: Glucose intolerance, hyperlipidemia, hypercholesterolemia, diabetic ketoacidosis, hypoglycemia[Ref]

Immunologic

Common (1% to 10%): Infections, sepsis[Ref]

Musculoskeletal

Common (1% to 10%): Pain in extremities[Ref]

Psychiatric

Frequency not reported: Confusion[Ref]

Respiratory

Common (1% to 10%): Hypoxia[Ref]

Other

Frequency not reported: Pyrexia[Ref]

Renal

Frequency not reported: Acute renal failure[Ref]

Dermatologic

Very common (10% or more): Rash

Frequency not reported: Toxic epidermal necrolysis (TEN), cerebrovascular accident, hemorrhage, superior sagittal sinus thrombosis[Ref]

References

1. "Product Information. Oncaspar (pegaspargase)." Rhone-Poulenc Rorer, Collegeville, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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