Oncaspar Side Effects
Generic name: pegaspargase
Medically reviewed by Drugs.com. Last updated on Jan 22, 2025.
Note: This document provides detailed information about Oncaspar.
Applies to pegaspargase: parenteral injection Side Effects associated with pegaspargase. Some dosage forms listed on this page may not apply specifically to the brand name Oncaspar.
Applies to pegaspargase: parenteral injection.
Side effects include:
Grade 3 or 4 reactions: Hypoalbuminemia, elevated serum aminotransferase concentrations, febrile neutropenia, hypertriglyceridemia, hyperglycemia, hyperbilirubinemia, pancreatitis, clotting study abnormalities, embolic and thrombotic events, hypersensitivity reactions.
No apparent difference in adverse effects following IV versus IM administration.
For healthcare professionals
Applies to pegaspargase: injectable solution.
General adverse events
The most commonly reported side effects were elevated transaminases and clinical allergic reactions to asparaginase (including bronchospasm, hypotension, laryngeal edema, local erythema or swelling, systemic rash, and urticaria).[Ref]
Hypersensitivity
- Very common (10% or more): Hypersensitivity, urticaria, anaphylactic reaction[Ref]
Nervous system
- Common (1% to 10%): Central nervous system thrombosis/hemorrhage, seizure, peripheral motor neuropathy, syncope
- Rare (less than 0.1%): Posterior reversible leukoencephalopathy syndrome
- Frequency not reported: Somnolence, tremor[Ref]
Cardiovascular
- Common (1% to 10%): Thrombosis, embolism[Ref]
Gastrointestinal
- Very common (10% or more): Pancreatitis, diarrhea, abdominal pain, nausea
- Common (1% to 10%): Vomiting, stomatitis, ascites
- Rare (less than 0.1%): Pancreatitis necrotizing, pancreatitis hemorrhagic
- Frequency not reported: Pancreatic pseudocyst, parotitis[Ref]
Hematologic
- Very common (10% or more): Febrile neutropenia
- Common (1% to 10%): Coagulopathy (prolonged prothrombin time or partial thromboplastin time; or hypofibrinogenemia), anemia
- Frequency not reported: Bone marrow failure[Ref]
Hepatic
- Very common (10% or more): Elevated transaminases
- Common (1% to 10%): Hyperbilirubinemia, hepatotoxicity, fatty liver
- Rare (0.01% to 0.1%): Hepatic necrosis, jaundice, cholestasis, hepatic failure[Ref]
Metabolic
- Common (1% to 10%): Hyperglycemia, weight decreased, decreased appetite
- Frequency not reported: Glucose intolerance, hyperlipidemia, hypercholesterolemia, diabetic ketoacidosis, hypoglycemia[Ref]
Immunologic
- Common (1% to 10%): Infections, sepsis[Ref]
Musculoskeletal
- Common (1% to 10%): Pain in extremities[Ref]
Psychiatric
- Frequency not reported: Confusion[Ref]
Respiratory
- Common (1% to 10%): Hypoxia[Ref]
Other
- Frequency not reported: Pyrexia[Ref]
Renal
- Frequency not reported: Acute renal failure[Ref]
Dermatologic
- Very common (10% or more): Rash
- Frequency not reported: Toxic epidermal necrolysis (TEN), cerebrovascular accident, hemorrhage, superior sagittal sinus thrombosis[Ref]
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References
1. (2001) "Product Information. Oncaspar (pegaspargase)." Rhone Poulenc Rorer
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Oncaspar side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.