Obagi Side Effects
Generic Name: tretinoin topical
Note: This document contains side effect information about tretinoin topical. Some of the dosage forms listed on this page may not apply to the brand name Obagi.
For the Consumer
Applies to tretinoin topical: topical cream, topical gel/jelly, topical liquid, topical solution
In some animal studies, tretinoin has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other studies have not shown the same result and more studies need to be done. It is not known if tretinoin causes skin tumors to develop faster in humans.
Along with its needed effects, tretinoin topical (the active ingredient contained in Obagi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking tretinoin topical:More common
- Burning feeling or stinging skin (severe)
- lightening of skin of treated area, unexpected
- peeling of skin (severe)
- redness of skin (severe)
- unusual dryness of skin (severe)
- Darkening of treated skin
Some side effects of tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Burning feeling, stinging, or tingling of skin (mild)—lasting for a short time after first applying the medicine
- chapping or slight peeling of skin (mild)
- redness of skin (mild)
- unusual dryness of skin (mild)
- unusually warm skin (mild)
The side effects will go away after you stop using tretinoin. On the rare chance that your skin color changes, this effect may last for several months before your skin color returns to normal.
For Healthcare Professionals
Applies to tretinoin topical: topical cream, topical gel, topical kit, topical liquid
Very common (10% or more): Severe skin irritation (Up to 32%)
Frequency not reported: Mild irritation, peeling/skin exfoliation, erythema, pruritus, blistering, pain, crusting, tenderness, dry skin, burning/warmth/stinging, photosensitivity/increased sensitivity to light
Postmarketing reports: Temporary hyper/hypopigmentation, rash, skin atrophy
Very common (10% or more): Dry skin (Up to 16%), peeling/scaling/flaking skin (Up to 12%)
Common (1% to 10%): Burning sensation, erythema, pruritus, skin pain, sunburn
Frequency not reported: Blistering/crusting skin
Postmarketing reports: Temporary hypo/hyperpigmentation, increased susceptibility to sunlight
Common (1% to 10%): Skin irritation, skin burning, erythema, dermatitis
Frequency not reported: Peeling, dryness, stinging, itching
Postmarketing reports: Temporary hypo/hyperpigmentation[Ref]
Erythema, peeling, dryness, burning/stinging, and/or itching occurred most frequently during the first 2 weeks of therapy.
Most of the dermatologic side effects were mild in severity (approximately 63%), and approximately 34% were of moderate severity.
Dry, peeling, scaling, and/or flaking skin occurred most often in the gel formulation.[Ref]
Frequency not reported: Reversible liver function test changes (bilirubin, alkaline phosphatase, ALT, AST)[Ref]
Frequency not reported: Thymol turbidity elevations, increased flocculation[Ref]
Postmarketing reports: Edema/swelling of application site[Ref]
Frequency not reported: Allergic contact dermatitis
Postmarketing reports: Allergic reaction[Ref]
1. Cerner Multum, Inc. "Australian Product Information." O 0
2. "Product Information. Renova (tretinoin topical)." Janssen Pharmaceuticals, Titusville, NJ.
3. "Product Information. Retin-A (tretinoin)." Ortho Pharmaceutical Corporation, Raritan, NJ.
4. "Product Information. Avita (tretinoin topical)." Penederm Inc, Foster City, CA.
Some side effects of Obagi may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about Obagi (tretinoin topical)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- 0 Reviews – Add your own review/rating
- Drug class: topical acne agents
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