Nicotinamide Side Effects

Applies to nicotinamide: compounding powder, oral capsule, oral capsule extended release, oral liquid, oral tablet, oral tablet extended release.

Cardiovascular adverse events

• Very common (10% or more): Flushing (i.e., warmth, redness, itching, and/or tingling) (up to 88%)
• Frequency not reported: Tachycardia, palpitations, atrial fibrillation, other cardiac arrhythmias, syncope, hypotension, postural hypotension^[Ref]

Dermatologic

• Common (1% to 10%): Rash, pruritus
• Frequency not reported: Sweating, skin burning sensation, maculopapular rash, dry skin
• Postmarketing reports: Skin discoloration^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 14%), nausea (up to 11%)
• Common (1% to 10%): Vomiting
• Frequency not reported: Peptic ulcers, eructation, flatulence^[Ref]

Hematologic

• Postmarketing reports: Slight reductions in platelet counts, prothrombin time prolonged^[Ref]

Hypersensitivity

• Postmarketing reports: Hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria, flushing, dyspnea, tongue edema, larynx edema, face edema, peripheral edema, laryngismus, vesiculobullous rash)^[Ref]

Hepatic

• Postmarketing reports: Hepatitis, jaundice^[Ref]

Metabolic

• Frequency not reported: Decreased glucose tolerance, gout^[Ref]

Musculoskeletal

• Frequency not reported: Myalgia, myopathy^[Ref]

Nervous system

• Frequency not reported: Dizziness, syncope
• Postmarketing reports: Migraine, asthenia, paresthesia^[Ref]

Ocular

• Postmarketing reports: Blurred vision, macular edema^[Ref]

Psychiatric

• Postmarketing reports: Insomnia, nervousness^[Ref]

Other

• Frequency not reported: Chills, edema^[Ref]

Respiratory

• Common (1% to 10%): Cough increased
• Frequency not reported: Dyspnea^[Ref]

See also:

Further information

Nicotinamide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer