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Neupogen Side Effects

Generic Name: filgrastim

Note: This document contains side effect information about filgrastim. Some of the dosage forms listed on this page may not apply to the brand name Neupogen.

For the Consumer

Applies to filgrastim: injection injectable, injection solution

Along with its needed effects, filgrastim (the active ingredient contained in Neupogen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking filgrastim:

More common
  • Abdominal or stomach pain
  • bleeding gums
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blood in the urine or stools
  • bloody nose
  • cough
  • coughing up blood
  • diarrhea
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • facial swelling
  • feeling of fullness
  • fever or chills
  • headache
  • increased menstrual flow or vaginal bleeding
  • lower back or side pain
  • nausea or vomiting
  • nosebleeds
  • pain in the back, ribs, arms, or legs
  • pain spreading to the left shoulder
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red or purple spots on the skin
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Blurred vision
  • chest pain
  • nervousness
  • pounding in the ears
  • slow or fast heartbeats
Incidence not known
  • Blisters on the skin
  • blue lips, fingernails, or skin
  • difficult or fast breathing
  • sores on the skin

Some side effects of filgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bone, joint, or muscle pain
  • hair loss or thinning of the hair
  • loss of appetite
  • weight loss
Less common
  • Cracked lips
  • difficulty having a bowel movement (stool)
  • swelling or inflammation of the mouth

For Healthcare Professionals

Applies to filgrastim: injectable solution


Common (1% to 10%): Hypotension
Uncommon (0.1% to 1%): Veno-occlusive diseased, fluid volume disturbances, capillary leak syndrome[Ref]


Very common (10% or more): Rash, alopecia
Uncommon (0.1% to 1%): Sweets syndrome, cutaneous vasculitis[Ref]


Very common (10% or more): Diarrhea, vomiting, constipation, nausea, mucosal inflammation[Ref]


Common (1% to 10%): Dysuria
Uncommon (0.1% to 1%): Urine abnormality, proteinuria, hematuria[Ref]


Very common (10% or more): Thrombocytopenia, leukocytosis, anemia, splenomegaly
Common (1% to 10%): Splenic rupture
Uncommon (0.1% to 1%): Sickle cell crisis[Ref]


Very common (10% or more): Gamma-glutamyltransferase increased, blood alkaline phosphatase increased, hepatomegaly
Uncommon (0.1% to 1%): Aspartate aminotransferase increased[Ref]


Common (1% to 10%): Hypersensitivity
Uncommon (0.1% to 1%): Graft versus host disease, anaphylactic reaction[Ref]


Common (1% to 10%): Injection site reaction[Ref]


Very common (10% or more): Blood uric acid increased, blood lactate dehydrogenase increased, decreased appetite, hyperuricemia, blood glucose decreased
Uncommon (0.1% to 1%): Pseudogout[Ref]


Very common (10% or more): Bone pain, back pain, arthralgia, myalgia, pain in extremity, musculoskeletal pain, musculoskeletal chest pain, neck pain
Common (1% to 10%): Osteoporosis
Uncommon (0.1% to 1%): Exacerbation of rheumatoid arthritis[Ref]

Nervous system

Very common (10% or more): Headache[Ref]


Very common (10% or more): Asthenia, fatigue, pain[Ref]


Common (1% to 10%): Glomerulonephritis[Ref]


Very common (10% or more): Oropharyngeal pain, cough, dyspnea, epistaxis
Common (1% to 10%): Hemoptysis
Uncommon (0.1% to 1%): Acute respiratory distress syndrome, respiratory failure, pulmonary edema, interstitial lung disease, lung infiltration, pulmonary hemorrhage[Ref]


1. "Product Information. Neupogen (filgrastim)." Amgen, Thousand Oaks, CA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Neupogen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.