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Neo/PolyB/HC Side Effects

Generic name: hydrocortisone / neomycin / polymyxin b ophthalmic

Medically reviewed by Last updated on Aug 29, 2022.

Note: This document contains side effect information about hydrocortisone / neomycin / polymyxin b ophthalmic. Some dosage forms listed on this page may not apply to the brand name Neo/PolyB/HC.

Applies to hydrocortisone/neomycin/polymyxin b ophthalmic: ophthalmic suspension.

Serious side effects of Neo/PolyB/HC

Along with its needed effects, hydrocortisone/neomycin/polymyxin b ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking hydrocortisone/neomycin/polymyxin b ophthalmic and get emergency help immediately if any of the following effects occur:


  • Fainting
  • lightheadedness (sudden and severe)
  • shortness of breath or trouble breathing (severe)
  • swelling around face

Check with your doctor immediately if any of the following side effects occur while taking hydrocortisone / neomycin / polymyxin b ophthalmic:

More common

  • Itching, rash, redness, swelling, or other sign of irritation not present before use of this medicine


  • Blurred vision or other change in vision
  • delayed healing of eye infection

Other side effects of Neo/PolyB/HC

Some side effects of hydrocortisone / neomycin / polymyxin b ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Burning or stinging when applying medicine

For Healthcare Professionals

Applies to hydrocortisone / neomycin / polymyxin b ophthalmic: ophthalmic suspension.


Adverse reactions have occurred with this combination of drugs which can be attributed to the corticosteroid component, the anti-infective component, or the combination; the exact incidence is unknown.[Ref]


Frequency not reported: Conjunctival erythema, itching, swelling, fungal infection of cornea, viral infection of cornea


-Frequency not reported: Intraocular pressure increased, glaucoma, posterior subcapsular cataract formation, optic nerve damage, wound healing delayed[Ref]


Frequency not reported: Allergic sensitization, anaphylaxis[Ref]


Frequency not reported: Secondary infection developed[Ref]


Frequency not reported: Irritation

More about Neo / PolyB / HC (hydrocortisone / neomycin / polymyxin b ophthalmic)

Professional resources

Related treatment guides


1. "Product Information. Cortisporin Ophthalmic (bacitracin/HC/neomycin/polymyxin B ophthalmic)." Allscrips Pharmaceutical Company

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.