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Neo / PolyB / HC Side Effects

Generic Name: hydrocortisone / neomycin / polymyxin b ophthalmic

Note: This document contains side effect information about hydrocortisone / neomycin / polymyxin b ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Neo / PolyB / HC.

For the Consumer

Applies to hydrocortisone / neomycin / polymyxin b ophthalmic: ophthalmic suspension

Along with its needed effects, hydrocortisone / neomycin / polymyxin b ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking hydrocortisone / neomycin / polymyxin b ophthalmic and get emergency help immediately if any of the following effects occur:

  • Fainting
  • lightheadedness (sudden and severe)
  • shortness of breath or trouble breathing (severe)
  • swelling around face

Check with your doctor immediately if any of the following side effects occur while taking hydrocortisone / neomycin / polymyxin b ophthalmic:

More common
  • Itching, rash, redness, swelling, or other sign of irritation not present before use of this medicine
  • Blurred vision or other change in vision
  • delayed healing of eye infection

Some side effects of hydrocortisone / neomycin / polymyxin b ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Burning or stinging when applying medicine

For Healthcare Professionals

Applies to hydrocortisone / neomycin / polymyxin b ophthalmic: ophthalmic suspension


Ocular side effects associated with the corticosteroid component of this drug include increased intraocular pressure with possible development of glaucoma and infrequent optic nerve damage, posterior subcapsular cataract formation, and delayed wound healing have been reported.

Bacterial, fungal, and viral secondary ocular infections, local irritation, visual disturbance (blurry vision) have also been reported with the use of ocular corticosteroids.[Ref]


Hypersensitivity reactions associated with the anti-infective component of this drug include allergic sensitization manifested by itching, swelling, and conjunctival erythema. More serious reactions such as anaphylaxis have rarely been reported.[Ref]

Neomycin is known to cause contact sensitivity.[Ref]


1. "Product Information. Cortisporin Ophthalmic Suspension (hydrocortisone/neomycin/polymyxin B ophth)." Allscripts Pharmaceutical Company, Vernon Hills, IL.

2. Prystowsky SD, Nonomura JH, Smith RW, Allen AM "Allergic hypersensitivity to neomycin. Relationship between patch test reactions and 'use' tests." Arch Dermatol 115 (1979): 713-5

3. Prystowsky SD, Allen AM, Smith RW, Nonomura JH, Odom RB, Akers WA "Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine. Relationships between age, sex, history of exposure, and reactivity to standard patch tests and use tests in a general population." Arch Dermatol 115 (1979): 959-62

Some side effects of Neo / PolyB / HC may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.