Nadofaragene Firadenovec Side Effects
Medically reviewed by Drugs.com. Last updated on May 25, 2024.
Applies to nadofaragene firadenovec: urinary bladder suspension.
Precautions
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests will be needed to check for unwanted effects.
If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting this medicine. Using this medicine while you are pregnant can harm your unborn baby. Female patients should use an effective form of birth control during treatment and for at least 6 months after the last dose. Male patients who have female partners should use an effective form of birth control during treatment and for at least 3 months after the last dose If you think you have become pregnant while using this medicine, tell your doctor right away.
Serious side effects
Along with its needed effects, nadofaragene firadenovec may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking nadofaragene firadenovec:
More common side effects
- blood in the urine
- burning while urinating
- chills
- difficult or painful urination
- fever
- trouble in holding or releasing urine
- unusual tiredness or weakness
Less common side effects
- anxiety
- arm, back, or jaw pain
- blurred vision
- chest pain, discomfort, heaviness, or tightness
- cold sweats
- coma
- confusion
- cool, pale skin
- decreased urination
- depression
- dizziness
- dry mouth
- fainting
- fast or irregular heartbeat
- headache
- lightheadedness
- nausea
- nervousness
- nightmares
- rapid breathing
- seizures
- shakiness
- slurred speech
- sunken eyes
- sweating
- thirst
- trouble breathing
- wrinkled skin
Rare side effects
- dilated neck veins
- blue or pale skin
- irregular breathing
- problems with movement, walking, or speech
- swelling of the face, fingers, feet, or lower legs
- vomiting
- weight gain
For healthcare professionals
Applies to nadofaragene firadenovec: intravesical suspension.
General adverse events
The most common adverse reactions reported in 10% or more patients including laboratory abnormalities in more than 15% patients, were increased glucose, instillation site discharge, increased triglycerides, fatigue, bladder spasm, micturition (urination) urgency, increased creatinine, hematuria (blood in urine), decreased phosphate, chills, dysuria, and pyrexia (fever).[Ref]
Cardiovascular
- Common (1% to 10%): Coronary artery disease, acute coronary syndrome, atrial fibrillation, heart failure, pericarditis[Ref]
Hematologic
- Very common (10% or more): Decreased hemoglobin (16%)[Ref]
Metabolic
- Very common (10% or more): Increased glucose (38%), increased triglycerides (30%), increased creatinine (17%), decreased phosphate (16%)
- Common (1% to 10%): Dehydration, hypoglycemia, bile duct stone[Ref]
Other
- Very common (10% or more): Instillation site discharge (33%), fatigue (24%), chills (16%), pyrexia (15%)
- Common (1% to 10%): Syncope, sepsis[Ref]
Renal
- Very common (10% or more): Bladder spasm (20%), micturition urgency (19%), hematuria (17%), dysuria (16%)[Ref]
Nervous system
- Common (1% to 10%): Brain edema[Ref]
See also:
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Padcev
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Anktiva
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Durvalumab
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References
1. (2022) "Product Information. Adstiladrin (nadofaragene firadenovec)." Ferring Pharmaceuticals Inc
More about nadofaragene firadenovec
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Further information
Nadofaragene firadenovec side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
