Nadofaragene Firadenovec Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 23, 2024.

Applies to nadofaragene firadenovec: urinary bladder suspension.

Serious side effects

Along with its needed effects, nadofaragene firadenovec may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking nadofaragene firadenovec:

More common side effects

• blood in the urine
• burning while urinating
• chills
• difficult or painful urination
• fever
• trouble in holding or releasing urine
• unusual tiredness or weakness

Less common side effects

• anxiety
• arm, back, or jaw pain
• blurred vision
• chest pain, discomfort, heaviness, or tightness
• cold sweats
• coma
• confusion
• cool, pale skin
• decreased urination
• depression
• dizziness
• dry mouth
• fainting
• fast or irregular heartbeat
• headache
• lightheadedness
• nausea
• nervousness
• nightmares
• rapid breathing
• seizures
• shakiness
• slurred speech
• sunken eyes
• sweating
• thirst
• trouble breathing
• wrinkled skin

Rare side effects

• dilated neck veins
• blue or pale skin
• irregular breathing
• problems with movement, walking, or speech
• swelling of the face, fingers, feet, or lower legs
• vomiting
• weight gain

For healthcare professionals

Applies to nadofaragene firadenovec: intravesical suspension.

General adverse events

The most common adverse reactions reported in 10% or more patients including laboratory abnormalities in more than 15% patients, were increased glucose, instillation site discharge, increased triglycerides, fatigue, bladder spasm, micturition (urination) urgency, increased creatinine, hematuria (blood in urine), decreased phosphate, chills, dysuria, and pyrexia (fever).^[Ref]

Cardiovascular

• Common (1% to 10%): Coronary artery disease, acute coronary syndrome, atrial fibrillation, heart failure, pericarditis^[Ref]

Hematologic

• Very common (10% or more): Decreased hemoglobin (16%)^[Ref]

Metabolic

• Very common (10% or more): Increased glucose (38%), increased triglycerides (30%), increased creatinine (17%), decreased phosphate (16%)
• Common (1% to 10%): Dehydration, hypoglycemia, bile duct stone^[Ref]

Other

• Very common (10% or more): Instillation site discharge (33%), fatigue (24%), chills (16%), pyrexia (15%)
• Common (1% to 10%): Syncope, sepsis^[Ref]

Renal

• Very common (10% or more): Bladder spasm (20%), micturition urgency (19%), hematuria (17%), dysuria (16%)^[Ref]

Nervous system

• Common (1% to 10%): Brain edema^[Ref]

Further information

Nadofaragene firadenovec side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer