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Mycelex Side Effects

Generic Name: clotrimazole topical

Note: This page contains information about the side effects of clotrimazole topical. Some of the dosage forms included on this document may not apply to the brand name Mycelex.

For the Consumer

Applies to clotrimazole topical: topical cream, topical lotion, topical solution

In addition to its needed effects, some unwanted effects may be caused by clotrimazole topical (the active ingredient contained in Mycelex). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking clotrimazole topical, check with your doctor or nurse as soon as possible:

  • Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine

For Healthcare Professionals

Applies to clotrimazole topical: compounding powder, topical cream, topical lotion, topical powder, topical solution, topical spray, vaginal cream with applicator, vaginal kit, vaginal tablet


Dermatologic side effects have included erythema, stinging, blistering, peeling, edema, itching, burning, and general skin irritation. Contact dermatitis, confirmed by patch testing, has been documented.[Ref]


Genitourinary system effects associated with intravaginal use have included burning, itching, cramping, pain, and bleeding. Vulvar lesions and rash have rarely been reported.[Ref]


1. "Product Information. Mycelex (clotrimazole)." Bayer, West Haven, CT.

2. Kalb RE, Grossman ME "Contact dermatitis to clotrimazole." Cutis 36 (1985): 240-2

3. Baes H "Contact dermatitis from clotrimazole." Contact Dermatitis 32 (1995): 187-8

4. Balato N, Lembo G, Nappa P, Ayala F "Contact dermatitis from clotrimazole." Contact Dermatitis 12 (1985): 110

5. Roller JA "Contact allergy to clotrimazole." Br Med J 2 (1978): 737

6. Lebherz TB, Ford LC, Kleinkopf V "A comparison of a three-day and seven-day clotrimazole regimen for vulvovaginal candidiasis." Clin Ther 3 (1981): 344-8

7. Lebherz T, Guess E, Wolfson N "Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis." Am J Obstet Gynecol 152 (1985): 965-8

8. Pons V, Greenspan D, Debruin M "Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. The Multicenter Study Group." J Acquir Immune Defic Syndr 6 (1993): 1311-6

9. Sawyer PR, Brogden RN, Pinder RM, Speight TM, Avery "Clotrimazole: a review of its antifungal activity and therapeutic efficacy." Drugs 9 (1975): 424-47

10. Stein GE, Christensen S, Mummaw N "Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis." DICP 25 (1991): 582-5

11. Wolfson N, Riley J, Samuels B, Singh JM "Clinical toxicology of clotrimazole when administered vaginally." Clin Toxicol 18 (1981): 41-5

12. Brown D Jr, Binder GL, Gardner HL, Wells J "Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis." Obstet Gynecol 56 (1980): 121-3

Not all side effects for Mycelex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.