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Multaq Side Effects

Generic Name: dronedarone

Medically reviewed by Last updated on Sep 13, 2020.

Note: This document contains side effect information about dronedarone. Some of the dosage forms listed on this page may not apply to the brand name Multaq.

In Summary

More frequent side effects include: abdominal pain, allergic dermatitis, diarrhea, eczema, nausea, pruritus, and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dronedarone: oral tablet


Oral route (Tablet)

In patients with symptomatic heart failure and recent decompensation requiring hospitalization or NYHA Class IV heart failure, dronedarone hydrochloride doubles the risk of death. Dronedarone hydrochloride is contraindicated in patients with symptomatic heart failure with recent decompensation requiring hospitalization or NYHA Class IV heart failure. In patients with permanent atrial fibrillation, dronedarone hydrochloride doubles the risk of death, stroke, and hospitalization for heart failure. Dronedarone hydrochloride is contraindicated in patients in atrial fibrillation (AF) who will not or cannot be cardioverted into normal sinus rhythm .

Side effects requiring immediate medical attention

Along with its needed effects, dronedarone (the active ingredient contained in Multaq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dronedarone:

Less common

Incidence not known

  • Abdominal or stomach pain, severe
  • chills
  • cough
  • dark urine
  • fever
  • general feeling of discomfort or illness
  • loss of appetite
  • nausea or vomiting
  • thickening of bronchial secretions
  • unusual tiredness or weakness
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of dronedarone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Acid or sour stomach
  • belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, or scaly skin
  • heartburn
  • indigestion
  • itching skin
  • rash
  • redness or discoloration of the skin
  • skin rash, encrusted, scaly, and oozing
  • skin rash, hives, itching, or redness
  • stomach discomfort, upset, or pain
  • swelling


  • Change in taste
  • increased sensitivity of the skin to sunlight
  • loss of taste
  • severe sunburn

For Healthcare Professionals

Applies to dronedarone: oral tablet


Very common (10% or more): QT prolongation (28%)

Common (1% to 10%): Bradycardia

Very rare (less than 0.01%): New or worsening heart failure, atrial flutter with 1:1 atrioventricular conduction[Ref]


Frequency not reported: Hypokalemia and hypomagnesemia with potassium-depleting diuretics, serum creatinine increased 10% or more within 5 days after treatment initiation[Ref]


Common (1% to 10%): Diarrhea, nausea, abdominal pain, vomiting, dyspeptic symptoms

Frequency not reported: Dysgeusia, ageusia[Ref]


Common (1% to 10%): Rashes (generalized, macular, maculopapular, erythematous), pruritus, eczema, dermatitis, allergic dermatitis

Uncommon (0.1% to 1%): Photosensitivity[Ref]


Common (1% to 10%): Asthenia, fatigue[Ref]


Frequency not reported: Liver injury, including acute liver failure requiring transplant, serum hepatic enzymes, serum bilirubin increase


Frequency not reported: Dyspnea, nonproductive cough

Postmarketing reports: Interstitial lung disease including pneumonitis and pulmonary fibrosis


Common (1% to 10%): Urinary tract infection


Postmarketing reports: Vasculitis, including leukocytoclastic vasculitis


Postmarketing reports: Anaphylactic reactions including angioedema


Frequency not reported: Increased serum creatinine[Ref]


1. "Product Information. Multaq (dronedarone)." sanofi-aventis , Bridgewater, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.