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Marinol Side Effects

Generic Name: dronabinol

Note: This document contains side effect information about dronabinol. Some of the dosage forms listed on this page may not apply to the brand name Marinol.

For the Consumer

Applies to dronabinol: oral capsule, oral capsule liquid filled, oral solution

Along with its needed effects, dronabinol (the active ingredient contained in Marinol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dronabinol:

Less common

  • Changes in mood
  • confusion
  • delusions
  • fast or pounding heartbeat
  • feelings of unreality
  • loss of memory
  • mental depression
  • nervousness or anxiety
  • problems with memory
  • seeing, hearing, or feeling things that are not there

Rare

  • Blurred vision
  • chills
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness

Incidence not known

  • Fainting
  • feeling of warmth
  • hives or rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • seizures
  • sores in the mouth
  • swelling of the lips
  • tightness in the throat
  • trouble sleeping

Get emergency help immediately if any of the following symptoms of overdose occur while taking dronabinol:

Symptoms of overdose

  • Being forgetful
  • change in how fast you think time is passing
  • change in your sense of smell, taste, sight, sound, or touch
  • constipation
  • decrease in motor coordination
  • drowsiness (severe)
  • dryness of the mouth (severe)
  • false sense of well-being
  • feeling sluggish
  • panic reaction
  • problems in urinating
  • redness of the eyes
  • seizures
  • slurred speech
  • unusual drowsiness or dullness

Some side effects of dronabinol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Clumsiness or unsteadiness
  • dizziness
  • drowsiness
  • false sense of well-being
  • nausea
  • trouble with thinking
  • vomiting

Less common or rare

  • Abdominal or stomach pain
  • flushing of the face
  • lack or loss of strength
  • restlessness

Rare

  • Burning, dry, or itching eyes
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • diarrhea
  • discharge, excessive tearing
  • headache
  • hearing loss
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • stuffy nose

For Healthcare Professionals

Applies to dronabinol: oral capsule, oral solution

Psychiatric

Very common (10% or more): Elation (up to 24%), feeling high/easy laughing (up to 24%), heightened awareness (up to 24%)
Common (1% to 10%): Abnormal thinking, euphoria, paranoid reaction
Frequency not reported: Anxiety/nervousness, confusion, depersonalization, depression, hallucinations, nightmares
Postmarketing reports: Delirium, disorientation, insomnia, panic attack[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, nausea, vomiting
Frequency not reported: Diarrhea, fecal incontinence
Postmarketing reports: Lip swelling, oral lesions[Ref]

Nervous system

Common (1% to 10%): Dizziness, somnolence
Frequency not reported: Amnesia, ataxia, headache, speech difficulties
Postmarketing reports: Fatigue, loss of consciousness, movement disorder, seizure/seizure-like activity, syncope[Ref]

Cardiovascular

Frequency not reported: Flushing, hypotension, palpitations, tachycardia, vasodilation/facial flush[Ref]

Other

Frequency not reported: Asthenia, chills, malaise, tinnitus
Postmarketing reports: Fall, fatigue[Ref]

Respiratory

Frequency not reported: Cough, rhinitis, sinusitis
Postmarketing reports: Throat tightness[Ref]

Ocular

Frequency not reported: Conjunctival injection, vision difficulties[Ref]

Dermatologic

Frequency not reported: Sweating
Postmarketing reports: Disseminated rash, hives, skin burning[Ref]

Hepatic

Frequency not reported: Hepatic enzyme elevation[Ref]

Musculoskeletal

Frequency not reported: Myalgia[Ref]

Metabolic

Frequency not reported: Anorexia[Ref]

References

1. "Product Information. Marinol (dronabinol)." Roxane Laboratories Inc, Columbus, OH.

2. "Product Information. Syndros (dronabinol)." Insys Therapeutics Inc, Phoenix, AZ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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