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Lotrimin AF Jock Itch Cream Side Effects

Generic name: clotrimazole topical

Medically reviewed by Last updated on Jul 14, 2022.

Note: This document contains side effect information about clotrimazole topical. Some dosage forms listed on this page may not apply to the brand name Lotrimin AF Jock Itch Cream.

Applies to clotrimazole topical: topical cream, topical solution.

Serious side effects

Along with its needed effects, clotrimazole topical (the active ingredient contained in Lotrimin AF Jock Itch Cream) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking clotrimazole topical:

  • Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine

For Healthcare Professionals

Applies to clotrimazole topical: compounding powder, topical cream, topical lotion, topical powder, topical solution, topical spray, vaginal cream with applicator, vaginal kit, vaginal tablet.


Dermatologic side effects have included erythema, stinging, blistering, peeling, edema, itching, burning, and general skin irritation. Contact dermatitis, confirmed by patch testing, has been documented.[Ref]


Genitourinary system effects associated with intravaginal use have included burning, itching, cramping, pain, and bleeding. Vulvar lesions and rash have rarely been reported.[Ref]

More about Lotrimin AF Jock Itch Cream (clotrimazole topical)

Patient resources

Other brands

Canesten, Mycelex, Clotrimazole-3, Desenex Antifungal Cream, FungiCURE Pump Spray

Professional resources

Other formulations

Related treatment guides


1. Roller JA "Contact allergy to clotrimazole." Br Med J 2 (1978): 737

2. Balato N, Lembo G, Nappa P, Ayala F "Contact dermatitis from clotrimazole." Contact Dermatitis 12 (1985): 110

3. Kalb RE, Grossman ME "Contact dermatitis to clotrimazole." Cutis 36 (1985): 240-2

4. "Product Information. Mycelex (clotrimazole)." Bayer (2001):

5. Baes H "Contact dermatitis from clotrimazole." Contact Dermatitis 32 (1995): 187-8

6. Lebherz T, Guess E, Wolfson N "Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis." Am J Obstet Gynecol 152 (1985): 965-8

7. Wolfson N, Riley J, Samuels B, Singh JM "Clinical toxicology of clotrimazole when administered vaginally." Clin Toxicol 18 (1981): 41-5

8. Pons V, Greenspan D, Debruin M "Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. The Multicenter Study Group." J Acquir Immune Defic Syndr 6 (1993): 1311-6

9. Brown D Jr, Binder GL, Gardner HL, Wells J "Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis." Obstet Gynecol 56 (1980): 121-3

10. Lebherz TB, Ford LC, Kleinkopf V "A comparison of a three-day and seven-day clotrimazole regimen for vulvovaginal candidiasis." Clin Ther 3 (1981): 344-8

11. Stein GE, Christensen S, Mummaw N "Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis." DICP 25 (1991): 582-5

12. Sawyer PR, Brogden RN, Pinder RM, Speight TM, Avery "Clotrimazole: a review of its antifungal activity and therapeutic efficacy." Drugs 9 (1975): 424-47

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.