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Lonsurf Side Effects

Generic name: tipiracil / trifluridine

Medically reviewed by Drugs.com. Last updated on Sep 14, 2023.

Note: This document contains side effect information about tipiracil / trifluridine. Some dosage forms listed on this page may not apply to the brand name Lonsurf.

Applies to tipiracil / trifluridine: oral tablet.

Serious side effects of Lonsurf

Along with its needed effects, tipiracil/trifluridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tipiracil / trifluridine:

More common

Less common

Other side effects of Lonsurf

Some side effects of tipiracil / trifluridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to tipiracil / trifluridine: oral tablet.

Hematologic

Very common (10% or more): Anemia (77%), neutropenia (67%), thrombocytopenia (42%)

Common (1% to 10%): Febrile neutropenia[Ref]

Other

Very common (10% or more): Asthenia/fatigue (52%), infections (27%), pyrexia (19%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (48%), diarrhea (32%), vomiting (28%), abdominal pain (21%)

Common (1% to 10%): Stomatitis (8%)[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, pulmonary emboli

Uncommon (0.1% to 1%): Interstitial lung disease[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%)[Ref]

Cardiovascular

Common (1% to 10%): QTc interval prolongation[Ref]

Nervous system

Common (1% to 10%): Dysgeusia[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infections[Ref]

Dermatologic

Common (1% to 10%): Alopecia[Ref]

Frequently asked questions

References

1. Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc. 2015.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.