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Lonsurf Side Effects

Generic Name: tipiracil / trifluridine

Note: This page contains information about the side effects of tipiracil / trifluridine. Some of the dosage forms included on this document may not apply to the brand name Lonsurf.

In Summary

Common side effects of Lonsurf include: infection, anemia, diarrhea, fatigue, fever, nausea, neutropenia, thrombocytopenia, vomiting, weakness, and decreased appetite. Other side effects include: alopecia, and dysgeusia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tipiracil / trifluridine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by tipiracil / trifluridine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking tipiracil / trifluridine:

More common:
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Bladder pain
  • bloody or cloudy urine
  • frequent urge to urinate
  • headache
  • muscle aches
  • stuffy or runny nose

Minor Side Effects

Some of the side effects that can occur with tipiracil / trifluridine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach pain
  • change in taste
  • decreased appetite
  • diarrhea
  • hair loss or thinning of the hair
  • lack or loss of strength
  • loss of taste
  • nausea
  • swelling or inflammation of the mouth
  • vomiting

For Healthcare Professionals

Applies to tipiracil / trifluridine: oral tablet

Hematologic

Very common (10% or more): Anemia (77%), neutropenia (67%), thrombocytopenia (42%)
Common (1% to 10%): Febrile neutropenia[Ref]

Other

Very common (10% or more): Asthenia/fatigue (52%), infections (27%), pyrexia (19%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (48%), diarrhea (32%), vomiting (28%), abdominal pain (21%)
Common (1% to 10%): Stomatitis (8%)[Ref]

General

3.6% of patients discontinued treatment for an adverse event; 13.7% required a dose reduction, most commonly for neutropenia, anemia, febrile neutropenia, fatigue, and diarrhea.[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, pulmonary emboli
Uncommon (0.1% to 1%): Interstitial lung disease[Ref]

Metabolic

Very common (10% or more): Decreased appetite (39%)[Ref]

Cardiovascular

Common (1% to 10%): QTc interval prolongation[Ref]

Nervous system

Common (1% to 10%): Dysgeusia[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infections[Ref]

Dermatologic

Common (1% to 10%): Alopecia[Ref]

References

1. "Product Information. Lonsurf (tipiracil-trifluridine)." Taiho Oncology, Inc., Princeton, NJ.

Not all side effects for Lonsurf may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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