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Leukine Side Effects

Generic Name: sargramostim

Note: This document contains side effect information about sargramostim. Some of the dosage forms listed on this page may not apply to the brand name Leukine.

For the Consumer

Applies to sargramostim: intravenous powder for solution, intravenous solution

Along with its needed effects, sargramostim (the active ingredient contained in Leukine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sargramostim:

More common
  • Abdominal pain
  • black, tarry stools
  • bloating or swelling of face, arms, hands, lower legs, or feet
  • blood in eye
  • bloody nose
  • bloody stools
  • blurred vision
  • body aches or pain
  • bone pain
  • chest pain
  • cloudy urine
  • congestion
  • cough
  • decrease in urine output or decrease in urine-concentrating ability
  • difficult or labored breathing
  • drowsiness
  • dry mouth
  • dryness or soreness of throat
  • eye pain
  • fast, pounding, or irregular heartbeat or pulse
  • fatigue
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • hoarseness
  • increased hunger
  • increased thirst
  • increased urination
  • irregular heartbeat
  • large amount of cholesterol in the blood
  • loss of appetite
  • mood or mental changes
  • muscle spasms [tetany] or twitching seizures
  • nausea or vomiting
  • rapid weight gain
  • redness in whites of eyes
  • runny nose
  • shortness of breath
  • sweating
  • tender, swollen glands in neck
  • tightness in chest
  • tingling of hands or feet
  • trouble in swallowing
  • troubled breathing
  • trembling
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • voice changes
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking sargramostim:

Symptoms of overdose
  • General feeling of discomfort or illness
  • headache
  • rash

Some side effects of sargramostim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Chills
  • diarrhea
  • difficulty in moving
  • fear or nervousness
  • itching skin
  • lack or loss of strength
  • muscle pain or stiffness
  • pain in joints
  • sleeplessness
  • trouble sleeping
  • unable to sleep

For Healthcare Professionals

Applies to sargramostim: injectable powder for injection, injectable solution

General

The type and frequency of adverse events following induction in patients with acute myelogenous leukemia (AML) were similar between those treated with this drug and those taking placebo.[Ref]

Other

Very common (10% or more): Fever (up to 95%), mucous membrane disorder (75%), asthenia (up to 66%), malaise (57%), edema (up to 34%), chills (up to 25%), pain (17%), chest pain (15%), peripheral edema (up to 15%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 90%), diarrhea (up to 89%), vomiting (up to 85%), stomatitis (up to 62%), abdominal pain (38%), gastrointestinal disorder (37%), gastrointestinal hemorrhage (up to 27%), dyspepsia (17%), hematemesis (13%), dysphagia (11%)
Common (1% to 10%): Constipation, abdominal distention[Ref]

Dermatologic

Very common (10% or more): Alopecia (up to 73%), rash (up to 70%), pruritus (23%)
Common (1% to 10%): Petechia, sweats[Ref]

Immunologic

Very common (10% or more): Infection (65%), allergy (12%), sepsis (11%)
Common (1% to 10%): Neutralizing antibodies
Frequency not reported: Allergic reaction, anaphylactoid reaction[Ref]

Metabolic

Very common (10% or more): Anorexia (up to 54%), glucose high (41%), weight loss (37%), hyperglycemia (25%), cholesterol high (17%), hypomagnesemia (15%)
Common (1% to 10%): Calcium low, weight gain[Ref]

Nervous system

Very common (10% or more): Headache (up to 36%), central nervous system disorder (11%), paresthesia (11%)
Frequency not reported: Dizziness
Postmarketing reports: Fainting[Ref]

Cardiovascular

Very common (10% or more): Hypertension (34%), hemorrhage (up to 29%), pericardial effusion (25%), hypotension (13%), tachycardia (11%)
Postmarketing reports: Arrhythmia, thrombosis[Ref]

Hepatic

Very common (10% or more): Bilirubinemia (30%), liver damage (13%), ALT increased (13%)
Common (1% to 10%): Alkaline phosphatase increased
Postmarketing reports: Transient liver function abnormalities[Ref]

Respiratory

Very common (10% or more): Dyspnea (28%), pharyngitis (23%), lung disorder (20%), epistaxis (17%), dyspnea (15%), rhinitis (11%)[Ref]

Hematologic

Very common (10% or more): Albumin low (27%), blood dyscrasia (25%), thrombocytopenia (19%), leukopenia (17%)
Common (1% to 10%): Agranulocytosis
Frequency not reported: Anemia, serum proteins low, prothrombin time prolonged, progressive increase in circulating monocytes and promonocytes and blasts in the marrow
Postmarketing reports: Eosinophilia[Ref]

Renal

Very common (10% or more): BUN high (23%), creatinine increased (15%)
Common (1% to 10%): Kidney function abnormal[Ref]

Musculoskeletal

Very common (10% or more): Bone pain (21%), arthralgia (up to 21%), myalgia (18%)
Common (1% to 10%): Back pain
Postmarketing reports: Joint pain[Ref]

Genitourinary

Very common (10% or more): Urinary tract disorder (14%)
Common (1% to 10%): Hematuria[Ref]

Psychiatric

Very common (10% or more): Insomnia (11%), anxiety (11%)[Ref]

Ocular

Very common (10% or more): Eye hemorrhage (11%)[Ref]

Local

Postmarketing reports: Injection site reactions[Ref]

References

1. "Product Information. Leukine (sargramostim)." Immunex Corporation, Seattle, WA.

Some side effects of Leukine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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