Kengreal Side Effects

Generic name: cangrelor

Medically reviewed by Drugs.com. Last updated on Jun 8, 2024.

Note: This document provides detailed information about Kengreal Side Effects associated with cangrelor. Some dosage forms listed on this page may not apply specifically to the brand name Kengreal.

Applies to cangrelor: intravenous powder for solution.

Serious side effects of Kengreal

Along with its needed effects, cangrelor (the active ingredient contained in Kengreal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cangrelor:

More common side effects

• abdominal or stomach pain or swelling
• back pain
• black, tarry stools
• blood in the eyes
• blood in the urine
• bruising or purple areas on the skin
• coughing up blood
• decreased alertness
• dizziness
• headache
• joint pain or swelling
• nosebleeds

Less common side effects

• difficult or labored breathing
• tightness in the chest

Rare side effects

• cough
• difficulty with swallowing
• fast heartbeat
• hives, itching, or rash
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• noisy breathing
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• unusual tiredness or weakness

For healthcare professionals

Applies to cangrelor: intravenous powder for injection.

General adverse events

The most common adverse reaction was bleeding.^[Ref]

Cardiovascular

• Very common (10% or more): Any Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding (15.5%), mild GUSTO bleeding (14.9%)
• Uncommon (0.1% to 1%): Severe/life-threatening GUSTO bleeding, moderate GUSTO bleeding, any Thrombolysis in Myocardial Infarction (TIMI) bleeding, major TIMI bleeding, minor TIMI bleeding
• Frequency not reported: Coronary artery dissection, coronary artery perforation^[Ref]

Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding definitions:

Severe/life-threatening GUSTO bleeding: Intracranial hemorrhage or bleeding resulting in substantial hemodynamic compromise requiring treatment.

Moderate GUSTO bleeding: Bleeding requiring blood transfusion but not resulting in hemodynamic compromise.

Mild GUSTO bleeding: All other bleeding not included in severe or moderate.

Thrombolysis in Myocardial Infarction (TIMI) bleeding definitions:

Major TIMI bleeding: Any intracranial hemorrhage or any overt bleeding associated with a reduction in hemoglobin of at least 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 15% or more).

Minor TIMI bleeding: Any overt sign of bleeding (including observation by imaging techniques) associated with a reduction in hemoglobin of 3 to less than 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 9% to less than 15%).^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea
• Frequency not reported: Bronchospasm, stridor^[Ref]

Renal

• Common (1% to 10%): Worsening renal function in patients with CrCl less than 30 mL/min^[Ref]

Immunologic

• Rare (less than 0.1%): Hypersensitivity
• Frequency not reported: Anaphylactic reactions, anaphylactic shock^[Ref]

Dermatologic

• Frequency not reported: Angioedema^[Ref]

Further information

Kengreal side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer