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Kengreal Side Effects

Generic Name: cangrelor

Note: This document contains side effect information about cangrelor. Some of the dosage forms listed on this page may not apply to the brand name Kengreal.

For the Consumer

Applies to cangrelor: intravenous powder for solution

Along with its needed effects, cangrelor (the active ingredient contained in Kengreal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cangrelor:

More common Less common
  • Difficult or labored breathing
  • tightness in the chest
  • Cough
  • difficulty with swallowing
  • fast heartbeat
  • hives, itching, or rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to cangrelor: intravenous powder for injection


The most common adverse reaction was bleeding.[Ref]


Very common (10% or more): Any Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding (15.5%), mild GUSTO bleeding (14.9%)
Uncommon (0.1% to 1%): Severe/life-threatening GUSTO bleeding, moderate GUSTO bleeding, any Thrombolysis in Myocardial Infarction (TIMI) bleeding, major TIMI bleeding, minor TIMI bleeding
Frequency not reported: Coronary artery dissection, coronary artery perforation[Ref]

Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding definitions:
-Severe/life-threatening GUSTO bleeding: Intracranial hemorrhage or bleeding resulting in substantial hemodynamic compromise requiring treatment.
-Moderate GUSTO bleeding: Bleeding requiring blood transfusion but not resulting in hemodynamic compromise.
-Mild GUSTO bleeding: All other bleeding not included in severe or moderate.

Thrombolysis in Myocardial Infarction (TIMI) bleeding definitions:
-Major TIMI bleeding: Any intracranial hemorrhage or any overt bleeding associated with a reduction in hemoglobin of at least 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 15% or more).
-Minor TIMI bleeding: Any overt sign of bleeding (including observation by imaging techniques) associated with a reduction in hemoglobin of 3 to less than 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 9% to less than 15%).[Ref]


Common (1% to 10%): Dyspnea
Frequency not reported: Bronchospasm, stridor[Ref]


Common (1% to 10%): Worsening renal function in patients with CrCl less than 30 mL/min[Ref]


Rare (less than 0.1%): Hypersensitivity
Frequency not reported: Anaphylactic reactions, anaphylactic shock[Ref]


Frequency not reported: Angioedema[Ref]


1. "Product Information. Kengreal (cangrelor)." The Medicines Company, Parsippany, NJ.

Some side effects of Kengreal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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