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Kengreal Side Effects

Generic Name: cangrelor

Note: This document contains side effect information about cangrelor. Some of the dosage forms listed on this page may not apply to the brand name Kengreal.

For the Consumer

Applies to cangrelor: intravenous powder for solution

Along with its needed effects, cangrelor (the active ingredient contained in Kengreal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cangrelor:

More common
  • Abdominal or stomach pain or swelling
  • back pain
  • black, tarry stools
  • blood in the eyes
  • blood in the urine
  • bruising or purple areas on the skin
  • coughing up blood
  • decreased alertness
  • dizziness
  • headache
  • joint pain or swelling
  • nosebleeds
Less common
  • Difficult or labored breathing
  • tightness in the chest
Rare
  • Cough
  • difficulty with swallowing
  • fast heartbeat
  • hives, itching, or rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to cangrelor: intravenous powder for injection

General

The most common adverse reaction was bleeding.[Ref]

Cardiovascular

Very common (10% or more): Any Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding (15.5%), mild GUSTO bleeding (14.9%)
Uncommon (0.1% to 1%): Severe/life-threatening GUSTO bleeding, moderate GUSTO bleeding, any Thrombolysis in Myocardial Infarction (TIMI) bleeding, major TIMI bleeding, minor TIMI bleeding
Frequency not reported: Coronary artery dissection, coronary artery perforation[Ref]

Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) bleeding definitions:
-Severe/life-threatening GUSTO bleeding: Intracranial hemorrhage or bleeding resulting in substantial hemodynamic compromise requiring treatment.
-Moderate GUSTO bleeding: Bleeding requiring blood transfusion but not resulting in hemodynamic compromise.
-Mild GUSTO bleeding: All other bleeding not included in severe or moderate.

Thrombolysis in Myocardial Infarction (TIMI) bleeding definitions:
-Major TIMI bleeding: Any intracranial hemorrhage or any overt bleeding associated with a reduction in hemoglobin of at least 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 15% or more).
-Minor TIMI bleeding: Any overt sign of bleeding (including observation by imaging techniques) associated with a reduction in hemoglobin of 3 to less than 5 g/dL (if hemoglobin is not available, an absolute reduction in hematocrit of 9% to less than 15%).[Ref]

Respiratory

Common (1% to 10%): Dyspnea
Frequency not reported: Bronchospasm, stridor[Ref]

Renal

Common (1% to 10%): Worsening renal function in patients with CrCl less than 30 mL/min[Ref]

Immunologic

Rare (less than 0.1%): Hypersensitivity
Frequency not reported: Anaphylactic reactions, anaphylactic shock[Ref]

Dermatologic

Frequency not reported: Angioedema[Ref]

References

1. "Product Information. Kengreal (cangrelor)." The Medicines Company, Parsippany, NJ.

Some side effects of Kengreal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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