Hylenex Side Effects

Generic name: hyaluronidase

Medically reviewed by Drugs.com. Last updated on Jun 30, 2023.

Note: This document contains side effect information about hyaluronidase. Some dosage forms listed on this page may not apply to the brand name Hylenex.

Applies to hyaluronidase: solution.

Serious side effects of Hylenex

Along with its needed effects, hyaluronidase (the active ingredient contained in Hylenex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hyaluronidase:

Rare

Cough
difficulty swallowing
dizziness
fast heartbeat
hives or welts
itching
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness of the skin
skin rash
tightness in the chest
unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking hyaluronidase:

Symptoms of overdose

Blurred vision
chills
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fast, pounding, or irregular heartbeat or pulse
nausea or vomiting
redness of the skin
sweating
swelling
unusual tiredness or weakness
unusually warm skin

Other side effects of Hylenex

Some side effects of hyaluronidase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to hyaluronidase: injectable powder for injection, injectable solution.

Hypersensitivity

Rare (less than 0.1%): Allergic reactions (e.g. urticaria, angioedema), anaphylactic-like reactions following retrobulbar block or intravenous injection^[Ref]

Local

Postmarketing reports: Local injection site reactions^[Ref]

Other

Postmarketing reports: Enhancement of adverse events of co-administered drugs; edema (reported most frequently in association with hypodermoclysis)^[Ref]