Granix Side Effects

Generic name: tbo-filgrastim

Medically reviewed by Drugs.com. Last updated on Jun 3, 2024.

Note: This document provides detailed information about Granix.

Applies to tbo-filgrastim: subcutaneous solution Side Effects associated with tbo-filgrastim. Some dosage forms listed on this page may not apply specifically to the brand name Granix.

Applies to tbo-filgrastim: subcutaneous solution.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Check with your doctor right away at the first sign of an infection, such as fever, chills, cough, sore throat, or unusual tiredness or weakness.

Check with your doctor right away if you or your child have pain in the upper left part of your stomach or at the tip of the left shoulder. These could be symptoms of a serious condition with the spleen.

Check with your doctor right away if you or your child have a fever, chest pain or tightness, or trouble breathing. These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS).

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have a rash, itching skin, dizziness, lightheadedness, or fainting, swelling of the face, tongue, or throat, trouble breathing, or chest pain after using the medicine.

This medicine may cause kidney problems. Call your doctor right away if you or your child have swelling in your face or ankles, blood in the urine, or a decrease in how much or how often you urinate.

This medicine may cause a condition called capillary leak syndrome. It can cause fluid to leak from the blood vessels into your body's tissues. Call your doctor right away if you or your child have swelling or puffiness, urinating less often, trouble breathing, feeling of fullness, dizziness, or feeling faint.

This medicine may cause aortitis (inflammation of the aorta, the largest artery in the body). Check with your doctor right away if you have fever, stomach pain, unusual tiredness or weakness, or back pain.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests (eg, bone-imaging test).

Serious side effects of Granix

Along with its needed effects, tbo-filgrastim (the active ingredient contained in Granix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking tbo-filgrastim:

Other side effects of Granix

Some side effects of tbo-filgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to tbo-filgrastim: subcutaneous solution.

Cardiovascular adverse events

• Very common (10% or more): Thrombocytopenia (up to 34%)
• Frequency not reported: Aortitis, capillary leak syndrome

In a clinical trial, thrombocytopenia occurred in 34% of pediatric patients (n=50) given 5 mcg/kg subcutaneously once a day starting one day after chemotherapy.

Gastrointestinal

• Common (1% to 10%): Diarrhea
• Frequency not reported: Vomiting^[Ref]

In a clinical trial, diarrhea occurred in 6% of pediatric patients (n=50) given 5 mcg/kg subcutaneously once a day starting one day after chemotherapy.^[Ref]

Musculoskeletal

• Common (1% to 10%): Bone pain, extremity pain
• Frequency not reported: Myalgia^[Ref]

In a clinical trial, extremity pain occurred in 6% of pediatric patients (n=50) given 5 mcg/kg subcutaneously once a day starting one day after chemotherapy.^[Ref]

Other

• Common (1% to 10%): Pyrexia
• Postmarketing reports: Asthenia, fatigue^[Ref]

In a clinical trial, pyrexia occurred in 8% of pediatric patients (n=50) given 5 mcg/kg subcutaneously once a day starting one day after chemotherapy.^[Ref]

Nervous system

• Common (1% to 10%): Headache

In a clinical trial, headache occurred in 6% of pediatric patients (n=50) given 5 mcg/kg subcutaneously once a day starting one day after chemotherapy.

Immunologic

• Common (1% to 10%): Anti-drug antibodies to this drug

Hematologic

• Frequency not reported: Fatal splenic rupture, leukocytosis, sickle cell disorders^[Ref]

Dermatologic

• Frequency not reported: Cutaneous vasculitis
• Postmarketing reports: Acute febrile neutrophilic dermatosis, Sweet's syndrome^[Ref]

Oncologic

• Frequency not reported: Potential for tumor growth stimulatory effects on malignant cells

Hypersensitivity

• Frequency not reported: Serious allergic reactions

Respiratory

• Frequency not reported: Acute respiratory distress syndrome

Renal

• Frequency not reported: Glomerulonephritis

See also:

Further information

Granix side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer