Folic acid Side Effects
Medically reviewed by Drugs.com. Last updated on Dec 7, 2020.
For the Consumer
Applies to folic acid: capsule, solution, tablet
Side effects requiring immediate medical attention
Along with its needed effects, folic acid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking folic acid:
- general weakness or discomfort
- reddened skin
- shortness of breath
- skin rash or itching
- tightness in chest
- troubled breathing
For Healthcare Professionals
Applies to folic acid: compounding powder, injectable solution, oral tablet
Nausea, abdominal distension, and flatulence were reported in patients taking 15 mg folic acid daily for 1 month.[Ref]
Bitter or bad taste, altered sleep patterns, difficulty concentrating, overactivity, and impaired judgement were reported in patients taking 15 mg folic acid daily for 1 month.
Rare (less than 0.1%): Anorexia
Anorexia was reported in patients taking 15 mg folic acid daily for 1 month.
Decreased vitamin B12 serum levels was reported with prolonged folic acid therapy.[Ref]
Decreased diphenylhydantoin serum levels were reported in patients taking 5 or 15 mg folic acid daily.[Ref]
Frequency not reported: Decreased diphenylhydantoin serum levels[Ref]
Frequency not reported: Irritability, excitement, mental depression, confusion[Ref]
Frequently asked questions
More about folic acid
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- Folic Acid Capsules and Tablets
- Folic Acid Injection
Related treatment guides
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Folic Acid (folic acid)." Method Pharmaceuticals, LLC, Arlington, TX.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.