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Feraheme Side Effects

Generic Name: ferumoxytol

Note: This document contains side effect information about ferumoxytol. Some of the dosage forms listed on this page may not apply to the brand name Feraheme.

For the Consumer

Applies to ferumoxytol: intravenous solution

Along with its needed effects, ferumoxytol (the active ingredient contained in Feraheme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ferumoxytol:

Less common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chest pain
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • rapid weight gain
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
Incidence not known
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • chest discomfort
  • cough
  • decreased urine output
  • difficulty with swallowing
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • hives, itching, or skin rash
  • irregular breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of consciousness
  • nausea or vomiting
  • no blood pressure or pulse
  • pain in the shoulders, arms, jaw, or neck
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • stopping of the heart
  • swelling of the face, fingers, feet, or lower legs
  • unconsciousness
  • unresponsiveness
  • weight gain

Some side effects of ferumoxytol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to ferumoxytol: intravenous solution


The most common adverse events were injection site reactions, gastrointestinal symptoms, headache, dizziness, and hypotension.[Ref]


Common (1% to 10%): Injection site reactions (infusion/injection site bruising, pain, reaction, swelling, warmth, hemorrhage, irritation, rash)[Ref]


Common (1% to 10%): Nausea, vomiting, abdominal pain (abdominal distension, abdominal pain upper, abdominal discomfort)
Uncommon (0.1% to 1%): Diarrhea, constipation, feces discolored
Rare (less than 0.1%): Dry mouth, dyspepsia, glossodynia
Frequency not reported: Lip swelling, swollen tongue[Ref]


Common (1% to 10%): Hypotension (hypotension, blood pressure decreased)
Uncommon (0.1% to 1%): Flushing (flushing, hot flush), hypertension (hypertension, accelerated hypertension)
Rare (less than 0.1%): Cardiac arrest, cardio-respiratory arrest, myocardial events, congestive heart failure
Frequency not reported: Tachycardia/arrhythmia, myocardial infarction, vasodilation, pulse absent
Postmarketing reports: Cyanosis[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Dysgeusia, somnolence, burning sensation
Rare (less than 0.1%): Paresthesia
Frequency not reported: Syncope, unresponsiveness, loss of consciousness[Ref]


Common (1% to 10%): Pruritus (pruritus generalized), rash (rash, rash generalized, rash pruritic, urticaria)
Uncommon (0.1% to 1%): Ecchymosis, sweating (hyperhidrosis, night sweats), skin hyperpigmentation, skin reaction
Frequency not reported: Angioedema[Ref]


Common (1% to 10%): Cough, dyspnea
Rare (less than 0.1%): Epistaxis
Frequency not reported: Bronchospasm, hyperventilation, hypoxia, laryngeal edema, pharyngeal edema, respiratory arrest, respiratory failure, throat irritation, throat tightness, wheezing[Ref]


Common (1% to 10%): Back pain, muscle spasms
Uncommon (0.1% to 1%): Muscle/joint pain or stiffness (arthralgia, myalgia, muscular weakness, musculoskeletal stiffness)[Ref]


Common (1% to 10%): Edema
Uncommon (0.1% to 1%): Decreased appetite, increased appetite
Rare (less than 0.1%): Dehydration, gout, hyperkalemia, blood glucose decreased
Frequency not reported: Oxygen saturation decreased[Ref]


Uncommon (0.1% to 1%): Hypersensitivity (including anaphylaxis)
Postmarketing reports: Life-threatening anaphylactic/anaphylactoid reactions[Ref]


Rare (less than 0.1%): Eosinophilia[Ref]


Rare (less than 0.1%): Hepatic function abnormal[Ref]


Common (1% to 10%): Peripheral edema, chest pain (chest discomfort, chest pain), fever (feeling hot, pyrexia)
Uncommon (0.1% to 1%): Fatigue (asthenia, fatigue), chills, serum ferritin increased, contusion[Ref]


Rare (less than 0.1%): Lacrimation increased, vision blurred[Ref]


Frequency not reported: Chronic renal failure[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Feraheme (ferumoxytol)." Alza Pharmaceuticals, Mountain View, CA.

Some side effects of Feraheme may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.