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Erythromycin / sulfisoxazole Side Effects

Applies to erythromycin / sulfisoxazole: oral powder for suspension

Side effects requiring immediate medical attention

Along with its needed effects, erythromycin / sulfisoxazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking erythromycin / sulfisoxazole:

More common

  • Itching
  • skin rash

Less common

  • Aching of joints and muscles
  • difficulty in swallowing
  • nausea or vomiting
  • pale skin
  • redness, blistering, peeling, or loosening of skin
  • skin rash
  • sore throat and fever
  • stomach pain, severe
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin


  • Blood in urine
  • dark or amber urine
  • irregular or slow heartbeat
  • temporary loss of hearing (with kidney disease and high doses)
  • lower back pain
  • pain or burning while urinating
  • pale stools
  • recurrent fainting
  • severe stomach pain
  • swelling of front part of neck

Check with your doctor as soon as possible if any of the following side effects occur while taking erythromycin / sulfisoxazole:

More common

  • Increased sensitivity to sunlight

Side effects not requiring immediate medical attention

Some side effects of erythromycin / sulfisoxazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach cramping and discomfort
  • diarrhea
  • headache
  • loss of appetite
  • nausea or vomiting

Less common

  • Sore mouth or tongue

Medically reviewed by Last updated on Dec 13, 2019.

More about erythromycin / sulfisoxazole

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Professional resources

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.