Erythromycin / Sulfisoxazole Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 28, 2024.

Applies to erythromycin / sulfisoxazole: oral granule for reconstitution.

Get emergency medical help if you have any of these signs of an allergic reaction while taking erythromycin / sulfisoxazole: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, erythromycin and sulfisoxazole can cause severe or life-threatening reactions. Stop using erythromycin and sulfisoxazole and call your doctor at once at the first sign of any skin rash, no matter how mild.

Call your doctor at once if you have:

• diarrhea that is watery or bloody;

• sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;

• pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

• headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

• new or worsening cough, fever, trouble breathing;

• nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

• vaginal itching or discharge; or

• mild nausea, vomiting, diarrhea, or stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:

Frequently asked questions

• What drugs should be avoided with a sulfa allergy?

Further information

Erythromycin/sulfisoxazole side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer