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Erwinaze Side Effects

Generic name: asparaginase erwinia chrysanthemi

Medically reviewed by Last updated on Feb 19, 2024.

Note: This document contains side effect information about asparaginase erwinia chrysanthemi. Some dosage forms listed on this page may not apply to the brand name Erwinaze.

Applies to asparaginase erwinia chrysanthemi: injection powder for solution. Other dosage forms:

Serious side effects of Erwinaze

Along with its needed effects, asparaginase erwinia chrysanthemi (the active ingredient contained in Erwinaze) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking asparaginase erwinia chrysanthemi:

More common

Less common

Incidence not known

Other side effects of Erwinaze

Some side effects of asparaginase erwinia chrysanthemi may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to asparaginase erwinia chrysanthemi: injectable powder for injection, intramuscular solution.


The most frequent nonhematological serious adverse reactions (in greater than 5% of patients) were febrile neutropenia, infection, drug hypersensitivity, pyrexia, nausea, dehydration, stomatitis, acute kidney injury, pancreatitis, diarrhea, and viral infection.[Ref]


Very common (15% or more): Hypersensitivity reactions including rash, infusion related reaction, lip swelling, periorbital edema, throat irritation, urticaria, dry skin, eczema, erythema, hand dermatitis, rash maculo-papular, rash papular (21% to 24%)

Very rare (less than 0.01%): Anaphylaxis[Ref]


Very common (15% or more): Stomatitis (24% to 27%), nausea (45% to 47%), abdominal pain (21% to 25%), diarrhea (18% to 25%), pancreatitis (12% to 22%)[Ref]

Nervous system

Very common (15% or more): Headache (22% to 36%), peripheral neuropathy including peripheral motor neuropathy, neuropathy peripheral, peripheral sensory neuropathy (6% to 15%)[Ref]


Common (1% to 10%): Rash (19%)

Frequency not reported: Toxic epidermal necrosis[Ref]


Very common (15% or more): Abnormal liver tests (70% to 75%)

Frequency not reported: Hepatomegaly, cholestatic jaundice[Ref]


Very common (15% or more): Febrile neutropenia (27% to 30%), hemorrhage including contusion, epistaxis, catheter site hemorrhage, petechiae, hematochezia, menorrhagia, mouth hemorrhage, increased tendency to bruise, rectal hemorrhage (24 to 27%)

Frequency not reported: clotting factor decreased, antithrombin III decreased, protein C decreased, protein S decreased, fibrinogen decreased[Ref]


Very common (reported as 15% or more): Tachycardia (16 to 18%)[Ref]


Very common (15% or more): Hyperglycemia (12% to 21%), hypokalemia (9% to 22%, dehydration (12% to 15%), decreased appetite (21% to 27%)

Rare (0.01% to 0.1%): Diabetic ketoacidosis

Very rare (less than 0.01%): Hyperammonemia[Ref]



Very common (15% or more): Including sepsis, upper respiratory tract infection, enterocolitis infectious, skin infection, bacteremia, paronychia, pneumonia, otitis externa, soft tissue infection, abdominal infection, conjunctivitis, device related infection, folliculitis, lymph gland infection, necrotizing fasciitis, perirectal abscess, peritonsillar abscess, sinusitis, subcutaneous abscess, wound infection (27% to 36%)[Ref]


Very common (15% or more): Musculoskeletal pain, including arthralgia, back pain, musculoskeletal chest pain, musculoskeletal pain, myalgia, pain in extremity (35% to 45%)[Ref]


Very common (15% or more): Insomnia (4% to 15%)[Ref]


Very common (15% or more): Cough (15%)[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. "Product Information. Erwinaze (asparaginase Erwinia chrysanthemi)." EUSA Pharma

3. (2022) "Product Information. Rylaze (asparaginase Erwinia chrysanthemi)." Jazz Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.