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Emverm Side Effects

Generic Name: mebendazole

Note: This page contains information about the side effects of mebendazole. Some of the dosage forms included on this document may not apply to the brand name Emverm.

For the Consumer

Applies to mebendazole: oral suspension, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by mebendazole (the active ingredient contained in Emverm). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking mebendazole:

Rare
  • Black, tarry stools
  • chills
  • convulsions
  • cough or hoarseness
  • dark urine
  • fever with or without chills
  • general feeling of tiredness or weakness
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • lower back or side pain
  • nausea and vomiting
  • painful or difficult urination
  • pale skin
  • redness of the skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • yellow eyes and skin
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • joint or muscle pain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • tightness in the chest

Minor Side Effects

Some of the side effects that can occur with mebendazole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Rare
  • Abdominal or stomach pain or upset
Incidence not known:
  • Bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • hair loss or thinning of the hair
  • loss of appetite
  • passing gas
  • weight loss

For Healthcare Professionals

Applies to mebendazole: compounding powder, oral tablet chewable

General

Since mebendazole (the active ingredient contained in Emverm) is not well absorbed, few systemic side effects are reported. Side effects may be more likely and more severe in patients with underlying liver disease.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, and abdominal pain, especially when the intestinal parasite burden is great.[Ref]

Hepatic

Increased liver function tests have been associated with mebendazole (the active ingredient contained in Emverm) in patients with hepatic hydatid cysts.[Ref]

Hepatic side effects have included transient changes in liver function tests and granulomatous hepatitis. These side effects have been reported when mebendazole was taken for prolonged periods and at dosages substantially above those recommended.[Ref]

Hematologic

Bone marrow biopsy results during mebendazole-associated leukopenia or pancytopenia have revealed hypocellularity. These effects reverse upon drug discontinuation.[Ref]

Hematologic side effects are unusual and reversible, but may be severe. Profound leukopenia, often accompanied by anemia and thrombocytopenia, has been reported. Pancytopenia and neutropenia have also been reported.[Ref]

Dermatologic

Dermatologic side effects have included rare reports of alopecia and angioedema. Rash, pruritus, urticaria, and flushing have also been reported.[Ref]

Other

No evidence of hypersensitivity (eosinophilia, rash, leukocytosis) accompanied the rare reports of drug fever. The fever may have been idiosyncratic or evidence of a reaction to drug-induced tissue necrosis in hydatid cysts.[Ref]

Other side effects have included chills and drug fever.[Ref]

Nervous system

Nervous system side effects have been reported rarely. These have included weakness, drowsiness, and seizures.[Ref]

References

1. Barrett-Connor E "Drugs for the treatment of parasitic infection." Med Clin North Am 66 (1982): 245-55

2. Bekhti A, Pirotte J "Hepatotoxicity of mebendazole: relationship with serum concentrations of the drug." Gastroenterol Clin Biol 11 (1987): 701-3

3. Witassek F, Bircher "Chemotherapy of larval echinococcosis with mebendazole: microsomal liver function and cholestasis as determinants of plasma drug level." Eur J Clin Pharmacol 25 (1983): 85-90

4. Kammerer WS, Schantz PM "Long term follow-up of human hydatid disease (echinococcus granulosus) treated with a high-dose mebendazole regimen." Am J Trop Med Hyg 33 (1984): 132-7

5. Miskovitz PF, Javitt NB "Leukopenia associated with mebendazole therapy of hydatid disease." Am J Trop Med Hyg 29 (1980): 1356-8

6. Colle I, Naegels S, Hoorens A, Hautekeete M "Granulomatous hepatitis due to mebendazole." J Clin Gastroenterol 28 (1999): 44-5

7. Levin MH, Weinstein RA, Axelrod JL, Schantz PM "Severe, reversible neutropenia during high-dose mebendazole therapy for echinococcosis." JAMA 249 (1983): 2929-31

8. Braithwaite PA, Thomas RJ, Thompson RC "Hydatid disease, the alveolar variety in australia: a case report with comment on the toxicity of mebendazole." Aust N Z J Surg 55 (1985): 519-23

9. Fernandez-Banares F, Gonzalez-Huix F, Xiol X, et al "Marrow aplasia during high dose mebendazole treatment." Am J Trop Med Hyg 35 (1986): 350-1

10. Murray-Lyon IM, Reynolds KW "Complication of mebendazole treatment for hydatid disease." Br Med J 2 (1979): 1111-2

11. "Multum Information Services, Inc. Expert Review Panel"

Not all side effects for Emverm may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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