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Ecoza Side Effects

Generic name: econazole topical

Medically reviewed by Last updated on May 12, 2022.

Note: This document contains side effect information about econazole topical. Some of the dosage forms listed on this page may not apply to the brand name Ecoza.

For the Consumer

Applies to econazole topical: topical cream, topical foam

Side effects requiring immediate medical attention

Along with its needed effects, econazole topical (the active ingredient contained in Ecoza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking econazole topical:

Less common

  • Burning, itching, stinging, redness, or other sign of irritation at the application site
  • rash

For Healthcare Professionals

Applies to econazole topical: compounding powder, topical cream, topical foam


Topical Cream:

-Common (1% to 10%): Pruritus/itching, skin burning sensation/burning, erythema

-Frequency not reported: Pruritic rash

-Postmarketing reports: Angioedema, contact dermatitis, rash, urticaria, blister, skin exfoliation

Vaginal Cream and Pessaries:

-Common (1% to 10%): Pruritus, skin burning sensation

-Uncommon (0.1% to 1%): Rash

-Rare (0.01% to 0.1%): Erythema

-Postmarketing reports: Angioedema, urticaria, contact dermatitis, skin exfoliation[Ref]


Topical Cream:

-Common (1% to 10%): Pain/stinging

-Uncommon (0.1% to 1%): Discomfort, swelling[Ref]


Vaginal Cream and Pessaries:

-Uncommon (0.1% to 1%): Vulvovaginal burning sensation[Ref]


One patient developed erythematous, edematous, urticarial-like lesions with vesiculation at the site of drug application. Sensitivity to this drug was confirmed by patch testing.[Ref]

Topical Cream:

-Frequency not reported: Lesions with vesiculation at site of application

Topical Foam:

-Uncommon (0.1% to 1%): Application site reactions

Vaginal Cream and Pessaries:

-Postmarketing reports: Application site pain, application site irritation, application site swelling[Ref]


Topical Cream:

-Frequency not reported: Drug sensitivity

-Postmarketing reports: Hypersensitivity

Vaginal Cream and Pessaries:

-Postmarketing reports: Hypersensitivity[Ref]


1. "Product Information. Spectazole (econazole)." Ortho Pharmaceutical Corporation, Raritan, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Day RM, Sefton J, Landow RK, Millikan LE, Nesbitt LT Jr, Galen WK, Gewirtzman GB, Horwitz SN, Roth HL "Naftifine cream 1% versus econazole cream 1% in the treatment of tinea cruris and tinea corporis." J Am Acad Dermatol 18 (1988): 52-6

4. Cainelli T, Tornaghi A, Tribbia G, Valsecchi R "Contact dermatitis from econazole." Contact Dermatitis 8 (1982): 422

5. Avery GS, Brogden RN, Heel RC, Speight TM "Econazole: a review of its antifungal activity and therapeutic efficacy." Drugs 16 (1978): 177-201

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.