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Ecoza Side Effects

Generic Name: econazole topical

Note: This document contains side effect information about econazole topical. Some of the dosage forms listed on this page may not apply to the brand name Ecoza.

For the Consumer

Applies to econazole topical: topical cream, topical foam, topical powder, topical solution

Along with its needed effects, econazole topical (the active ingredient contained in Ecoza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking econazole topical:

Less common
  • Burning, itching, stinging, redness, or other sign of irritation at the application site
  • rash

For Healthcare Professionals

Applies to econazole topical: compounding powder, topical cream, topical foam


Topical Cream:
-Common (1% to 10%): Pruritus/itching, skin burning sensation/burning, erythema
-Frequency not reported: Pruritic rash
-Postmarketing reports: Angioedema, contact dermatitis, rash, urticaria, blister, skin exfoliation

Vaginal Cream and Pessaries:
-Common (1% to 10%): Pruritus, skin burning sensation
-Uncommon (0.1% to 1%): Rash
-Rare (0.01% to 0.1%): Erythema
-Postmarketing reports: Angioedema, urticaria, contact dermatitis, skin exfoliation[Ref]


Topical Cream:
-Common (1% to 10%): Pain/stinging
-Uncommon (0.1% to 1%): Discomfort, swelling[Ref]


Vaginal Cream and Pessaries:
-Uncommon (0.1% to 1%): Vulvovaginal burning sensation[Ref]


One patient developed erythematous, edematous, urticarial-like lesions with vesiculation at the site of drug application. Sensitivity to this drug was confirmed by patch testing.[Ref]

Topical Cream:
-Frequency not reported: Lesions with vesiculation at site of application

Topical Foam:
-Uncommon (0.1% to 1%): Application site reactions

Vaginal Cream and Pessaries:
-Postmarketing reports: Application site pain, application site irritation, application site swelling[Ref]


Topical Cream:
-Frequency not reported: Drug sensitivity
-Postmarketing reports: Hypersensitivity

Vaginal Cream and Pessaries:
-Postmarketing reports: Hypersensitivity[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Spectazole (econazole)." Ortho Pharmaceutical Corporation, Raritan, NJ.

3. Millikan LE, Galen WK, Gewirtzman GB, Horwitz SN, Landow RK, Nesbitt LT Jr, Roth HL, Sefton J, Day RM "Naftifine cream 1% versus econazole cream 1% in the treatment of tinea cruris and tinea corporis." J Am Acad Dermatol 18 (1988): 52-6

4. Heel RC, Brogden RN, Speight TM, Avery GS "Econazole: a review of its antifungal activity and therapeutic efficacy." Drugs 16 (1978): 177-201

5. Valsecchi R, Tornaghi A, Tribbia G, Cainelli T "Contact dermatitis from econazole." Contact Dermatitis 8 (1982): 422

Some side effects of Ecoza may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.