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Dytan-HC Side Effects

Generic Name: diphenhydramine / hydrocodone / phenylephrine

Note: This document contains side effect information about diphenhydramine / hydrocodone / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name Dytan-HC.

Applies to diphenhydramine / hydrocodone / phenylephrine: oral suspension extended release, oral syrup

Nervous system

Nervous system side effects have included lightheadedness, nervousness, dizziness, drowsiness, sedation, mental clouding, headache, insomnia, tremors, weakness, lethargy, hallucinations, convulsions, impairment of mental and physical performance, anxiety, fear, dysphoria, psychic dependence, itchy and prickly sensations, and mood changes.[Ref]


Gastrointestinal side effects have included difficulty swallowing, dry mouth, anorexia, nausea, vomiting, and heartburn.[Ref]


Genitourinary side effects have included ureteral spasm, spasm of vesicle sphincters, urinary retention, and dysuria.[Ref]


Cardiovascular side effects have included pallor, tachycardia, palpitations, irregular heart beat, arrhythmias and cardiovascular collapse with hypotension.[Ref]


Respiratory side effects have included respiratory difficulty and shortness of breath.[Ref]


Ocular side effects have included blurring of vision.[Ref]


Dermatologic side effects have included rare reports of dermatitis.[Ref]


1. "Product Information. Tussinate (diphenhydramine / hydrocodone / phenylephrine)." PediaMed Pharmaceuticals Inc, Florence, KY.

Some side effects of Dytan-HC may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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