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Dronabinol Side Effects

For the Consumer

Applies to dronabinol: oral capsule, oral capsule liquid filled, oral solution

Along with its needed effects, dronabinol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dronabinol:

Less common
  • Changes in mood
  • confusion
  • delusions
  • fast or pounding heartbeat
  • feelings of unreality
  • loss of memory
  • mental depression
  • nervousness or anxiety
  • problems with memory
  • seeing, hearing, or feeling things that are not there
Rare
  • Blurred vision
  • chills
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Fainting
  • feeling of warmth
  • hives or rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • seizures
  • sores in the mouth
  • swelling of the lips
  • tightness in the throat
  • trouble sleeping

Get emergency help immediately if any of the following symptoms of overdose occur while taking dronabinol:

Symptoms of overdose
  • Being forgetful
  • change in how fast you think time is passing
  • change in your sense of smell, taste, sight, sound, or touch
  • constipation
  • decrease in motor coordination
  • drowsiness (severe)
  • dryness of the mouth (severe)
  • false sense of well-being
  • feeling sluggish
  • panic reaction
  • problems in urinating
  • redness of the eyes
  • seizures
  • slurred speech
  • unusual drowsiness or dullness

Some side effects of dronabinol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Clumsiness or unsteadiness
  • dizziness
  • drowsiness
  • false sense of well-being
  • nausea
  • trouble with thinking
  • vomiting
Less common or rare
  • Abdominal or stomach pain
  • flushing of the face
  • lack or loss of strength
  • restlessness
Rare
  • Burning, dry, or itching eyes
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • diarrhea
  • discharge, excessive tearing
  • headache
  • hearing loss
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • stuffy nose

For Healthcare Professionals

Applies to dronabinol: oral capsule, oral solution

Psychiatric

Very common (10% or more): Elation (up to 24%), feeling high/easy laughing (up to 24%), heightened awareness (up to 24%)
Common (1% to 10%): Abnormal thinking, euphoria, paranoid reaction,
Frequency not reported: Anxiety/nervousness, confusion, depersonalization, depression, hallucinations, nightmares
Postmarketing reports: Delirium, disorientation, insomnia, panic attack[Ref]

Nervous system

Common (1% to 10%): Dizziness, somnolence
Frequency not reported: Amnesia, ataxia, headache, speech difficulties
Postmarketing reports: Fatigue, loss of consciousness, movement disorder, seizure/seizure-like activity, syncope[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Hypotension, flushing
Frequency not reported: Palpitations, tachycardia, vasodilation/facial flush[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, nausea, vomiting
Uncommon (0.1% to 1%): Diarrhea
Frequency not reported: Fecal incontinence
Postmarketing reports: Lip swelling, oral lesions[Ref]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis
Frequency not reported: Conjunctival injection, vision difficulties[Ref]

Other

Frequency not reported: Asthenia, chills, malaise, tinnitus
Postmarketing reports: Fall, fatigue[Ref]

Musculoskeletal

Frequency not reported: Myalgia[Ref]

Hepatic

Frequency not reported: Hepatic enzyme elevation[Ref]

Metabolic

Frequency not reported: Anorexia[Ref]

Respiratory

Frequency not reported: Cough, rhinitis, sinusitis
Postmarketing reports: Throat tightness[Ref]

Dermatologic

Frequency not reported: Sweating
Postmarketing reports: Disseminated rash, hives, skin burning[Ref]

References

1. "Product Information. Marinol (dronabinol)." Roxane Laboratories Inc, Columbus, OH.

2. "Product Information. Syndros (dronabinol)." Insys Therapeutics Inc, Phoenix, AZ.

Some side effects of dronabinol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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