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Dostinex Side Effects

Generic name: cabergoline

Medically reviewed by Last updated on Jul 29, 2023.

Note: This document contains side effect information about cabergoline. Some dosage forms listed on this page may not apply to the brand name Dostinex.

Applies to cabergoline: oral tablet.

Serious side effects of Dostinex

Along with its needed effects, cabergoline (the active ingredient contained in Dostinex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cabergoline:

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking cabergoline:

Symptoms of overdose

Other side effects of Dostinex

Some side effects of cabergoline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


Incidence not known

For Healthcare Professionals

Applies to cabergoline: oral tablet.


Very common (10% or more): Nausea (up to 29%)

Common (1% to 10%): Constipation, dyspepsia, gastritis, vomiting, abdominal pain, dyspepsia, dry mouth, diarrhea, flatulence, throat irritation, toothache[Ref]

Nervous system

Very common (10% or more): Headache (up to 26%), dizziness (up to 17%)

Common (1% to 10%): Dizziness/vertigo, dyskinesia, paresthesia, somnolence

Uncommon (0.1% to 1%): Hyperkinesia

Frequency not reported: Sudden sleep onset, syncope, tremor[Ref]


Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Fatigue, malaise[Ref]


Common (1% to 10%): Hallucinations sleep disturbance, increased libido, confusion, depression, anxiety, insomnia, nervousness

Uncommon (0.1% to 1%): Delusions, psychotic disorder

Frequency not reported: Aggression, hypersexuality, pathological gambling[Ref]


Very common (10% or more): Peripheral edema

Common (1% to 10%): Angina (with concomitant levodopa use), postural hypotension, hot flashes, cardiac valvulopathy, hypotension, dependent edema, palpitation

Uncommon (0.1% to 1%): Erythromelalgia

Rare (less than 0.1%): Syncope, heart failure

Frequency not reported: Constrictive pericarditis, digital vasospasm

Postmarketing reports: Cardiac valvulopathy, pericarditis, pericardial effusion[Ref]

Reports of cardiac valvulopathy have generally been received in patients on higher doses (greater than 2 mg/day); however, there have been cases in patients receiving lower doses for the treatment of hyperprolactinemic disorders. In a multi-country, retrospective cohort study, record review looking for an association between the new use of dopamine agonists (including this drug; n=27,812) and cardiac valvular regurgitation (CVR), other fibrosis, and other cardiopulmonary events found an increased risk of CVR among patients with Parkinson's disease when compared to non-ergot derived dopamine agonists and levodopa. Analysis in patients with hyperprolactinemia treated with this drug (n=8386) found that compared to non-users, exposed persons did not have an elevated risk of CVR. These findings are consistent with other published studies.[Ref]


Frequency not reported: Leg cramps[Ref]


Uncommon (0.1% to 1%): Rash, acne, pruritus

Frequency not reported: Alopecia[Ref]


Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Pleural effusion, pulmonary fibrosis, rhinitis

Very rare (less than 0.01%): Fibrosis (including pleural fibrosis)

Frequency not reported: Respiratory disorder, respiratory failure, pleuritic, chest pain[Ref]


Uncommon (0.1% to 1%): Periorbital edema, abnormal vision[Ref]


Common (1% to 10%): Breast pain

Uncommon (0.1% to 1%): Dysmenorrhea[Ref]


Adverse effects are generally dose related. At lower doses, the more commonly reported adverse reactions included nausea, headache, dizziness/vertigo, abdominal pain/dyspepsia/gastritis, asthenia/fatigue; at higher doses, additional events of valvulopathy, dyspnea, dyskinesia, orthostatic hypotension, hallucination, and constipation have been commonly reported.[Ref]


Uncommon (0.1% to 1%): Hepatic function abnormalities

Postmarketing reports: Liver function test abnormal[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reaction[Ref]


1. "Multum Information Services, Inc. Expert Review Panel"

2. (2001) "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.