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Donepezil / memantine Side Effects

For the Consumer

Applies to donepezil / memantine: oral capsule delayed release, oral capsule extended release

Along with its needed effects, donepezil / memantine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking donepezil / memantine:

Incidence not known
  • Bloody or black, tarry stools
  • chest pain or discomfort
  • decreased urination
  • lightheadedness, dizziness, or fainting
  • pain in the lower abdomen, groin, upper back or sides
  • seizures
  • severe stomach pain
  • slow or irregular heartbeat
  • sweating
  • trouble breathing
  • unusual tiredness
  • vomiting of blood or material that looks like coffee grounds

Some side effects of donepezil / memantine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Constipation
  • decreased appetite
  • diarrhea
  • nausea
  • vomiting

For Healthcare Professionals

Applies to donepezil / memantine: oral capsule extended release, oral kit

Cardiovascular

Memantine:
Common (1% to 10%): Hypertension, hypotension
Postmarketing reports: Congestive cardiac failure

Donepezil:
Common (1% to 10%): Hypertension, hemorrhage, syncope
Postmarketing reports: Heart block (all types)[Ref]

Nervous system

Memantine:
Common (1% to 10%): Headache, dizziness, somnolence

Donepezil:
Common (1% to 10%): Headache, dizziness, somnolence
Postmarketing reports: Convulsions, neuroleptic malignant syndrome[Ref]

Gastrointestinal

Memantine:
Common (1% to 10%): Diarrhea, constipation, abdominal pain, vomiting
Postmarketing reports: Pancreatitis

Donepezil:
Very common (10% or more): Diarrhea (10%)
Common (1% to 10%): Vomiting, anorexia, nausea
Postmarketing reports: Abdominal pain, pancreatitis[Ref]

Respiratory

Memantine:
Common (1% to 10%): Influenza[Ref]

General

The most common adverse reactions in patients receiving memantine ER were headache, diarrhea, and dizziness. The most common adverse reactions in patients receiving donepezil were diarrhea, anorexia, vomiting, nausea, and ecchymosis.[Ref]

Dermatologic

Memantine:
Postmarketing reports: Stevens Johnson Syndrome

Donepezil:
Common (1% to 10%): Eczema
Postmarketing reports: Rash[Ref]

Hematologic

Memantine:
Postmarketing reports: Agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura

Donepezil:
Common (1% to 10%): Ecchymosis
Postmarketing reports: Hemolytic anemia[Ref]

Hepatic

Memantine:
Postmarketing reports: Hepatitis

Donepezil:
Postmarketing reports: Cholecystitis, hepatitis[Ref]

Metabolic

Donepezil:
Common (1% to 10%): Increased creatinine phosphokinase, dehydration, hyperlipidemia
Postmarketing reports: Hyponatremia[Ref]

Musculoskeletal

Memantine:
Common (1% to 10%): Back pain

Donepezil:
Common (1% to 10%): Back pain[Ref]

Other

Memantine:
Common (1% to 10%): Increased weight

Donepezil:
Very common (10% or more): Accident (13%), infection (11%)
Common (1% to 10%): Fever, pain, chest pain[Ref]

Psychiatric

Memantine:
Common (1% to 10%): Anxiety, depression, aggression
Postmarketing reports: Suicidal ideation

Donepezil:
Common (1% to 10%): Insomnia, nervousness, hallucinations, hostility, depression, confusion, emotional lability, personality disorder
Postmarketing reports: Agitation, confusion, hallucinations[Ref]

Renal

Memantine:
Common (1% to 10%): Urinary incontinence
Postmarketing reports: Acute renal failure

Donepezil:
Common (1% to 10%): Urinary incontinence[Ref]

References

1. "Product Information. Namzaric (donepezil-memantine)." Forest Pharmaceuticals, St. Louis, MO.

Some side effects of donepezil / memantine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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