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Diphtheria toxoid / pertussis, acellular / tetanus toxoid Side Effects

Medically reviewed by Last updated on Jul 29, 2023.

Applies to diphtheria toxoid / pertussis, acellular / tetanus toxoid: intramuscular suspension.

Serious side effects

Along with its needed effects, diphtheria toxoid/pertussis, acellular/tetanus toxoid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking diphtheria toxoid / pertussis, acellular / tetanus toxoid:

Less common


Incidence not known

Other side effects

Some side effects of diphtheria toxoid / pertussis, acellular / tetanus toxoid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to diphtheria toxoid / pertussis, acellular / tetanus toxoid: intramuscular suspension.


The most common adverse event was pain at the injection site.[Ref]


Very common (10% or more): Injection site pain (87.1%), injection site erythema (24.7%), injection site swelling (21%)

Postmarketing reports: Large (over 50 mm) injection site reactions, extensive limb swelling from the injection site beyond one or both joints, injection site bruising, sterile abscess[Ref]

Nervous system

Very common (10% or more): Headache (43.7%),

Frequency not reported: Severe migraine with unilateral facial paralysis, nerve compression in neck and left arm

Postmarketing reports: Paresthesia, hypoesthesia, Guillain-Barre syndrome, brachial neuritis, facial palsy, convulsion, syncope, myelitis[Ref]


Very common (10% or more): Body ache or muscle weakness (30.4%), chills (15.1%), sore and swollen joints (11.3%)

Common (1% to 10%): Myalgia

Postmarketing reports: Myositis, muscle spasm[Ref]


Very common (10% or more): Nausea (13.3%), diarrhea (10.3%)

Common (1% to 10%): Vomiting[Ref]


Postmarketing reports: Anaphylactic reaction, hypersensitivity reaction (angioedema, edema, rash, hypotension), Arthus hypersensitivity[Ref]


Very common (10% or more): Tiredness (30.2%), chills (15.1%)

Common (1% to 10%): Fever, malaise[Ref]


Common (1% to 10%): Rash

Postmarketing reports: Pruritus, urticaria[Ref]


Postmarketing reports: Myocarditis[Ref]


Common (1% to 10%): Lymph node swelling[Ref]


1. "Product Information. Adacel (Tdap) (tetanus/diphth/pertuss (Tdap) adult/adol)." Aventis Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.