Generic name: diphtheria, tetanus, and acellular pertussis vaccine (intramuscular route) [ dif-THEER-ee-a-TOX-oyd, ad-SORBD, per-TUS-iss-VAX-een, a-SELL-yoo-lar, TET-a-nus-TOX-oyd ]
Drug class: Vaccine combinations
Medically reviewed by Drugs.com. Last updated on Mar 11, 2022.
The Tripedia (DTaP) brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Vaccine
Uses for Tripedia
Diphtheria, tetanus, and acellular pertussis vaccine (also known as DTaP) is a combination immunizing agent given by injection to protect against infections caused by diphtheria, tetanus (lockjaw), and pertussis (whooping cough). This vaccine is given only to children 6 weeks through 6 years of age (before the child's 7th birthday).
Diphtheria is a serious illness that can cause breathing difficulties, heart problems, nerve damage, pneumonia, and possibly death. The risk of serious complications and death is greater in very young children and in the elderly.
Tetanus (also known as lockjaw) is a serious illness that causes convulsions (seizures) and severe muscle spasms that can be strong enough to cause bone fractures of the spine. Tetanus causes death in 30 to 40 percent of cases.
Pertussis (also known as whooping cough) is a serious disease that causes severe spells of coughing that can interfere with breathing. Pertussis also can cause pneumonia, long-lasting bronchitis, seizures, brain damage, and death.
Diphtheria, tetanus, and pertussis are serious diseases that can cause life-threatening illnesses. Although some serious side effects can occur after a dose of DTaP (usually from the pertussis vaccine part), this rarely happens. The chance of your child catching one of these diseases, and being permanently injured or dying as a result, is much greater than the chance of your child getting a serious side effect from the DTaP vaccine.
This vaccine is to be administered only by or under the supervision of your child's doctor or other health care professional.
Before using Tripedia
In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of diphtheria, tetanus, and acellular pertussis vaccine in children younger than 6 weeks of age and in children 7 years of age and older. Safety and efficacy have not been established.
Diphtheria, tetanus, and acellular pertussis vaccine is not recommended for use in adult populations.
No information is available on the relationship of age to the effects of Daptacel® in geriatric patients.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding disorders (eg, hemophilia, thrombocytopenia)—Should not use in patients with this condition.
- Brain disease (eg, encephalopathy)—This includes a coma, a decreased level of consciousness, or seizures lasting a long time. Children who have these symptoms within 7 days of receiving a vaccine with pertussis should not get this vaccine.
- Guillain-Barré syndrome (nerve disease that causes paralysis), history of—If your child had this condition after getting a vaccine with tetanus toxoid in it, you should talk to your doctor about the potential benefits and possible risks of getting this vaccine.
- Immunodeficiency disorder or
- Weakened immune system—This vaccine may not work as well in children with this condition.
- Previous serious reaction to a vaccine—If your child had a serious reaction to this vaccine or another vaccine with pertussis in it, you should talk to your doctor about the potential benefits and possible risks of getting this vaccine. Some serious reactions include being less responsive than normal, crying continuously without stopping for 3 hours or more, having a seizure with or without a fever, or having a fever that was 105 degrees F or higher.
- Progressive neurologic disorder—This includes infantile spasms, progressive brain disease, or uncontrolled seizures. This vaccine should not be given until these conditions are treated and under control.
Proper use of Tripedia
This section provides information on the proper use of a number of products that contain diphtheria, tetanus, and acellular pertussis vaccine. It may not be specific to Tripedia. Please read with care.
A nurse or other trained health professional will give your child this vaccine. The vaccine is given as a shot into one of your child's muscles.
This vaccine is usually given as a series of 4 or 5 shots. It is important that your child receive all of the shots in this series. Try to keep all scheduled appointments. If your child must miss a shot, make another appointment with the child's doctor as soon as possible.
Your child may receive other vaccines at the same time as this one, but in a different body area. You should receive information sheets about all of the vaccines your child receives. Make sure you understand all of the information that is given to you.
Your child may also receive a medicine to help prevent or treat some of the minor side effects of the vaccine, like fever and soreness.
Precautions while using Tripedia
It is very important that the doctor check your child at regular visits to make sure this vaccine is working properly and to check for unwanted effects. It is very important that you return to your child's doctor for the next dose in the series.
Contact your doctor immediately if your child has sudden weakness in the arms and legs. This could be a sign of a serious condition called Guillain-Barré syndrome.
It is very important to tell the doctor if your child is allergic to rubber. The vial and syringes may contain dry natural latex rubber, which may cause an allergic reaction if your child has a latex allergy.
This vaccine will not treat an active infection. If your child has an infection due to diphtheria, tetanus, or pertussis, your child will need medicines to treat these infections.
Syncope (fainting) may occur after receiving this vaccine. Your doctor may want your child to be observed after receiving the injection to prevent and manage fainting.
Be sure to tell your child's doctor about any side effects that occur after your child receives the vaccine. This may include seizures, fever, crying that will not stop, or severe redness or swelling where the shot was given.
This vaccine may cause apnea (breathing stops for short periods) in some premature infants. Discuss this with your child's doctor if you are concerned.
Make sure your doctor knows if you are using medicines that weaken your immune system such as cancer medicines, radiation treatment, or steroids.
Tripedia side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Collapse or shock-like state
- crying for 3 hours or more
- fever over 102.2 °F
- redness or swelling of 4 inches or more at the injection site
- seizures (convulsions)
- severe pain at the injection site
Incidence not known
- back pain
- black, tarry stools
- bleeding gums
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- blood in the urine or stools
- bloody nose
- bluish color of the fingernails, lips, skin, palms, or nail beds
- blurred vision
- difficulty with swallowing
- fast heartbeat
- joint pain, stiffness, or swelling
- loss of bladder control
- loss of consciousness
- loss of strength or energy
- muscle pain or weakness
- nausea and vomiting
- pain or cramping in the abdomen or stomach
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rash with flat lesions or small raised lesions on the skin
- shortness of breath
- sleepiness or unusual drowsiness
- sore throat
- stiff neck
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tightness in the chest
- total body jerking
- unusual bleeding or bruising
- unusual tiredness or weakness (sudden and severe)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Fever of 99.5 °F or more
- loss of appetite
- mild pain, redness, swelling, or tenderness at the injection site
- weight loss
Incidence not known
- ear pain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about Tripedia (DTaP) (diphtheria and tetanus toxoids / pertussis, acellular)
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.