Diphenhydramine / hydrocodone / phenylephrine Side Effects
For the Consumer
Applies to diphenhydramine / hydrocodone / phenylephrine: syrup
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking diphenhydramine / hydrocodone / phenylephrine:
Dizziness; drowsiness, excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor.
For Healthcare Professionals
Applies to diphenhydramine / hydrocodone / phenylephrine: oral suspension extended release, oral syrup
Nervous system side effects have included lightheadedness, nervousness, dizziness, drowsiness, sedation, mental clouding, headache, insomnia, tremors, weakness, lethargy, hallucinations, convulsions, impairment of mental and physical performance, anxiety, fear, dysphoria, psychic dependence, itchy and prickly sensations, and mood changes.[Ref]
Gastrointestinal side effects have included difficulty swallowing, dry mouth, anorexia, nausea, vomiting, and heartburn.[Ref]
Genitourinary side effects have included ureteral spasm, spasm of vesicle sphincters, urinary retention, and dysuria.[Ref]
Cardiovascular side effects have included pallor, tachycardia, palpitations, irregular heart beat, arrhythmias and cardiovascular collapse with hypotension.[Ref]
Respiratory side effects have included respiratory difficulty and shortness of breath.[Ref]
Ocular side effects have included blurring of vision.[Ref]
Dermatologic side effects have included rare reports of dermatitis.[Ref]
1. "Product Information. Tussinate (diphenhydramine / hydrocodone / phenylephrine)." PediaMed Pharmaceuticals Inc, Florence, KY.
Not all side effects for diphenhydramine / hydrocodone / phenylephrine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about diphenhydramine/hydrocodone/phenylephrine
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- Dosage Information
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- Drug class: upper respiratory combinations
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