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Desenex Spray Side Effects

Generic name: tolnaftate topical

Medically reviewed by Last updated on Apr 18, 2022.

Note: This document contains side effect information about tolnaftate topical. Some of the dosage forms listed on this page may not apply to the brand name Desenex Spray.

For the Consumer

Applies to tolnaftate topical: topical cream, topical powder, topical solution, topical spray

Side effects requiring immediate medical attention

Along with its needed effects, tolnaftate topical (the active ingredient contained in Desenex Spray) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking tolnaftate topical:

  • Skin irritation not present before use of this medicine

When you apply the aerosol solution form of this medicine, a mild temporary stinging may be expected.

For Healthcare Professionals

Applies to tolnaftate topical: compounding powder, topical aerosol powder, topical cream, topical ointment, topical powder, topical solution, topical spray


A case of sensitization to butylated hydroxytoluene which is found in some of the tolnaftate topical (the active ingredient contained in Desenex Spray) preparations has been reported.[Ref]

Dermatologic side effects have included a mild skin irritation.[Ref]

More about Desenex Spray (tolnaftate topical)

Patient resources

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Professional resources

Other formulations

Related treatment guides


1. "Product Information. Tinactin (tolnaftate topical)." Southwood Pharmaceuticals Inc (2002):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.