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Deoxycholic acid Side Effects

For the Consumer

Applies to deoxycholic acid: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by deoxycholic acid. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking deoxycholic acid, check with your doctor or nurse immediately:

Less common:
  • Headache
  • muscle weakness in the face
  • pain in the mouth or throat
  • pounding in the ears
  • slow or fast heartbeat
  • trouble swallowing
  • uneven smile
Incidence not known:
  • Fainting
  • neck pain
  • swollen, painful, or tender lymph glands in the neck

Minor Side Effects

Some of the side effects that can occur with deoxycholic acid may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Bleeding, blistering, bruising, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tightness of the skin, tingling, ulceration, or warmth at the injection site
Less common:
  • Nausea

For Healthcare Professionals

Applies to deoxycholic acid: subcutaneous solution


Common (1% to 10%): Oropharyngeal pain, nausea, dysphagia[Ref]


Very common (10% or more): Injection site reactions (96%): edema/swelling (87%), hematoma/bruising (72%), pain (70%), numbness (66%), erythema (27%), induration (23%), paresthesia (14%), nodule (13%), pruritus (12%),
Common (1% to 10%): Injection site reactions: skin tightness, site warmth, marginal mandibular nerve injury
Frequency not reported: Injection site reactions: hemorrhage, discoloration, urticaria[Ref]


Common (1% to 10%): Hypertension[Ref]


Frequency not reported: Lymphadenopathy[Ref]


Frequency not reported: Neck pain[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Pre-syncope/syncope[Ref]


1. "Product Information. Kybella (deoxycholic acid)." Kythera Biopharmaceuticals, Inc., Westlake Village, CA.

Not all side effects for deoxycholic acid may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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